Details:

Alternative Title:
PLoS One
Personal Author:
Jeisy-Scott, Victoria ; Davis, William G. ; Patel, Jenish R. ; Bowzard, John Bradford ; Shieh, Wun-Ju ; ... More +
Jeisy-Scott, Victoria ; Davis, William G. ; Patel, Jenish R. ; Bowzard, John Bradford ; Shieh, Wun-Ju ; Zaki, Sherif R. ; Katz, Jacqueline M. ; Sambhara, Suryaprakash ; Less -
Description:
Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune response against influenza A virus (IAV) infection; however, the role of Toll-like receptor 7 (TLR7) during the innate immune response to IAV infection and the cell types affected by the absence of TLR7 are not clearly understood. In this study, we show that myeloid derived suppressor cells (MDSC) accumulate in the lungs of TLR7 deficient mice more so than in wild-type C57Bl/6 mice, and display increased cytokine expression. Furthermore, there is an increase in production of Th2 cytokines by TLR7(-/-) compared with wildtype CD4+ T-cells in vivo, leading to a Th2 polarized humoral response. Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response.
Subject:
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Animals
Biology
CD4-Positive T-Lymphocytes
Cytokines
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunity, Innate
Influenza A Virus
Lung
Medicine
Mice
Mice, Inbred C57BL
Myeloid Cells
Research Article
Th2 Cells
Toll-Like Receptor 7

Source:
PLoS One. 2011 ; 6(9).;
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:89cd530e841e49a053d6539b88b443bacfcea3129d5e99cf996bc542dc90281a
File Type:

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