Polybrominated diphenyl ether exposure and reproductive hormones in North American men

Makey, Colleen M.; McClean, Michael D.; Braverman, Lewis E.; Pearce, Elizabeth N.; Sjödin, Andreas; Weinberg, Janice; Webster, Thomas F.

doi:10.1016/j.reprotox.2016.04.009

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Polybrominated diphenyl ether exposure and reproductive hormones in North American men

Published Date:

Apr 14 2016

Publisher's site:

http://dx.doi.org/10.1016/j.reprotox.2016.04.009 New Site Icon

Source:

Reprod Toxicol. 62:46-52.

[PDF - 359.57 KB]

Details:

Personal Authors:

Makey, Colleen M. ; McClean, Michael D. ; Braverman, Lewis E. ; Pearce, Elizabeth N. ; Sjödin, Andreas ; ... More ▼

Keywords:

[+]

Pubmed ID:

27094376

Pubmed Central ID:

PMC5152616

Description:

Background

Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function.

Objectives

To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort.

Methods

From 2010–11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models.

Results

PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH).

Conclusions

These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States
R01 ES015829/ES/NIEHS NIH HHS/United States
T32 ES014562/ES/NIEHS NIH HHS/United States

Supporting Files:

NIHMS832676-supplement-Supplemental.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
nihms832676.nxml	application/octet-stream

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