Polybrominated diphenyl ether exposure and reproductive hormones in North American men

Makey, Colleen M.; McClean, Michael D.; Braverman, Lewis E.; Pearce, Elizabeth N.; Sjödin, Andreas; Weinberg, Janice; Webster, Thomas F.

doi:10.1016/j.reprotox.2016.04.009

i

Polybrominated diphenyl ether exposure and reproductive hormones in North American men

Supporting Files

Apr 14 2016
By Makey, Colleen M. ; McClean, Michael D. ; Braverman, Lewis E.
http://dx.doi.org/10.1016/j.reprotox.2016.04.009
Available in CDC Stacks on 2017-07-01T00:00:00Z

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English

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Alternative Title:

Reprod Toxicol
Personal Author:

Makey, Colleen M. ; McClean, Michael D. ; Braverman, Lewis E. ; Pearce, Elizabeth N. ; Sjödin, Andreas ; Weinberg, Janice ; Webster, Thomas F.
Description:

Background ; Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function. ; Objectives ; To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort. ; Methods ; From 2010–11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models. ; Results ; PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH). ; Conclusions ; These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.
Subjects:
Source:

Reprod Toxicol. 62:46-52.
Pubmed ID:

27094376
Pubmed Central ID:

PMC5152616
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States ; R01 ES015829/ES/NIEHS NIH HHS/United States ; T32 ES014562/ES/NIEHS NIH HHS/United States
Place as Subject:

United States
Volume:

62
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https://stacks.cdc.gov/view/cdc/43211/cdc_43211_DS1.pdf
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[PDF - 359.57 KB]
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CDC Public Access
Main Document Checksum:

urn:sha256:10a3156ee6df677cbeb419891ef8b8dbaadd530c0fd869183dc530ae2f9e1279

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