In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: The CHAMACOS study

Details

• Alternative Title:
  Int J Hyg Environ Health
• Personal Author:
  Eskenazi, Brenda ; Rauch, Stephen A. ; Tenerelli, Rachel ; Huen, Karen ; Holland, Nina T. ; Lustig, Robert H. ; Kogut, Katherine ; Bradman, Asa ; Sjodin, Andreas ; Harley, Kim G.
• Description:
  Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the relationship of in utero and childhood exposure to these purported EDCs and reproductive hormones in adolescent boys who participated in CHAMACOS, an ongoing birth cohort in California's Salinas Valley. We measured o,p'- and p,p'-DDT, p,p'-DDE, PBDEs and PCBs in serum collected from mothers during pregnancy or at delivery and from their sons at 9 years. We measured concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (T) from 234 of their sons at 12 years. In adjusted models, we found that a 10-fold increase in maternal prenatal serum concentrations of BDE-153 was associated with a 22.2% increase (95% CI: 1.0, 47.9) in FSH, a 96.6% increase (95% CI: 35.7, 184.7) in LH, and a 92.4% increase (95% CI: 20.9, 206.2) increase in T. Similarly, BDE-100 concentrations were associated with increases in boys' LH levels. A 10-fold increase in total prenatal ΣPCBs was associated with a 64.5% increase (95% CI: 8.6, 149.0) in FSH, primarily driven by non- dioxin-like congeners. Boys' hormone levels were only marginally associated with prenatal DDT or DDE in primary models, but when boys' Tanner stage at age 12 was added to models, prenatal maternal DDT levels were associated with decreases in LH (adjusted percent change per 10-fold increase=-18.5%, 95% CI: -29.8, -5.4) and T (percent change=-18.2%, 95% CI: -30.2, -4.2) and DDE with LH (percent change=-18.3%, 95% CI: -32.9, -0.6). Exposures measured in the children's serum at 9 years also showed associations between BDE-153 and ΣPCBs. However, there is evidence that these associations appear to be mediated by child BMI. This study suggests associations on male hormones of 12year old boys related to exposure to certain EDC exposure prenatally. The implications on future reproductive function in puberty and adulthood should be determined.
• Subjects:
  Adolescent Adult Child Dichlorodiphenyl Dichloroethylene Endocrine Disruptors Environmental Monitoring Environmental Pollutants Female Flame Retardants Follicle Stimulating Hormone Halogenated Diphenyl Ethers Humans Luteinizing Hormone Male Maternal Exposure Middle Aged Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Testosterone Young Adult

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• Source:
  Int J Hyg Environ Health. 220(2 Pt B):364-372.
• Pubmed ID:
  27876543
• Pubmed Central ID:
  PMC5382037
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; P01 ES009605/ES/NIEHS NIH HHS/United States ; R01 ES015572/ES/NIEHS NIH HHS/United States
• Volume:
  220
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:41045233525ec281b5204e9233425f0167882e525766cf8347d5105b298d469c
• Download URL:
  https://stacks.cdc.gov/view/cdc/45009/cdc_45009_DS1.pdf
• File Type:
  [PDF - 384.38 KB ]