Details:

Alternative Title:
PLoS One
Personal Author:
Fry, Alicia M. ; Chittaganpitch, Malinee ; Baggett, Henry C. ; Peret, Teresa C. T. ; Dare, Ryan K. ; ... More +
Fry, Alicia M. ; Chittaganpitch, Malinee ; Baggett, Henry C. ; Peret, Teresa C. T. ; Dare, Ryan K. ; Sawatwong, Pongpun ; Thamthitiwat, Somsak ; Areerat, Peera ; Sanasuttipun, Wichai ; Fischer, Julie ; Maloney, Susan A. ; Erdman, Dean D. ; Olsen, Sonja J. Less -
Description:
Background

We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand.

Methods

From September 1, 2003 through December 31, 2007, we enrolled hospitalized patients with acute lower respiratory tract illness, who had a chest radiograph ordered by the physician, from all hospitals in SaKaeo and Nakhom Phanom Provinces. We tested nasopharyngeal specimens for RSV with reverse transcriptase polymerase chain reaction (RT-PCR) assays and paired-sera from a subset of patients with IgG enzyme immunoassay. Rates were adjusted for enrollment.

Results

Among 11,097 enrolled patients, 987 (8.9%) had RSV infection. Rates of hospitalized RSV infection overall (and radiographically-confirmed pneumonia) were highest among children aged <1 year: 1,067/100,000 (534/100,000 radiographically-confirmed pneumonia) and 1–4 year: 403/100,000 (222/100,000), but low among enrolled adults aged ≥65 years: 42/100,000. Age <1 year (adjusted odds ratio [aOR]  = 13.2, 95% confidence interval [CI] 7.7, 22.5) and 1–4 year (aOR = 8.3, 95% CI 5.0, 13.9) were independent predictors of hospitalized RSV infection.

Conclusions

The incidence of hospitalized RSV lower respiratory tract illness among children <5 years was high in rural Thailand. Efforts to prevent RSV infection could substantially reduce the pneumonia burden in children aged <5 years.


Subject:
[+]
Adolescent
Adult
Aged
Age Factors
Child
Child, Preschool
Hospitalization
Humans
Incidence
Infant
Infant, Newborn
Middle Aged
Pneumonia
Population Surveillance
Respiratory Syncytial Viruses
Respiratory Syncytial Virus Infections
Respiratory Tract Infections
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Rural Population
Young Adult

Source:
PLoS One. 5(11).
Document Type:
Journal Article
Place as Subject:
Thailand
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8405d73cc657dba3eec164800e43bcc0db8c514495b7ac34273f01551d528921
File Type:

Supporting Files

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