The Burden of Hospitalized Lower Respiratory Tract Infection due to Respiratory Syncytial Virus in Rural Thailand

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Fry, Alicia M. ; Chittaganpitch, Malinee ; Baggett, Henry C. ; Peret, Teresa C. T. ; Dare, Ryan K. ; Sawatwong, Pongpun ; Thamthitiwat, Somsak ; Areerat, Peera ; Sanasuttipun, Wichai ; Fischer, Julie ; Maloney, Susan A. ; Erdman, Dean D. ; Olsen, Sonja J.
• Description:
  Background
  
  We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand.
  
  Methods
  
  From September 1, 2003 through December 31, 2007, we enrolled hospitalized patients with acute lower respiratory tract illness, who had a chest radiograph ordered by the physician, from all hospitals in SaKaeo and Nakhom Phanom Provinces. We tested nasopharyngeal specimens for RSV with reverse transcriptase polymerase chain reaction (RT-PCR) assays and paired-sera from a subset of patients with IgG enzyme immunoassay. Rates were adjusted for enrollment.
  
  Results
  
  Among 11,097 enrolled patients, 987 (8.9%) had RSV infection. Rates of hospitalized RSV infection overall (and radiographically-confirmed pneumonia) were highest among children aged <1 year: 1,067/100,000 (534/100,000 radiographically-confirmed pneumonia) and 1–4 year: 403/100,000 (222/100,000), but low among enrolled adults aged ≥65 years: 42/100,000. Age <1 year (adjusted odds ratio [aOR]  = 13.2, 95% confidence interval [CI] 7.7, 22.5) and 1–4 year (aOR = 8.3, 95% CI 5.0, 13.9) were independent predictors of hospitalized RSV infection.
  
  Conclusions
  
  The incidence of hospitalized RSV lower respiratory tract illness among children <5 years was high in rural Thailand. Efforts to prevent RSV infection could substantially reduce the pneumonia burden in children aged <5 years.
  
  
• Subjects:
  Adolescent Adult Aged Age Factors Child Child, Preschool Hospitalization Humans Incidence Infant Infant, Newborn Middle Aged Pneumonia Population Surveillance Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Respiratory Tract Infections Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Rural Population Young Adult

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• Source:
  PLoS One. 5(11).
• Document Type:
  Journal Article
• Place as Subject:
  Thailand
• Volume:
  5
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8405d73cc657dba3eec164800e43bcc0db8c514495b7ac34273f01551d528921
• Download URL:
  https://stacks.cdc.gov/view/cdc/4302/cdc_4302_DS1.pdf
• File Type:
  [PDF - 426.42 KB ]