Welcome to CDC Stacks | Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study - 42989 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study
  • Published Date:
    Oct 19 2016
  • Source:
    Environ Res. 152:102-108.


Public Access Version Available on: January 01, 2018 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    27770710
  • Pubmed Central ID:
    PMC5135609
  • Description:
    Background

    Lead (Pb) exposure has been associated with poorer cognitive function cross-sectionally in aging adults, however the association between cumulative Pb exposure and longitudinal changes in cognition is little characterized.

    Methods

    In a 1993–2007 subcohort of the VA Normative Aging Study (Mini-mental status exam (MMSE) n=741; global cognition summary score n=715), we used linear mixed effects models to test associations between cumulative Pb exposure (patella or tibia bone Pb) and repeated measures of cognition (MMSE, individual cognitive tests, and global cognition summary). Cox proportional hazard modeling assessed the risk of an MMSE score falling below 25.

    Results

    Among men 51–98 at baseline, higher patella Pb concentration (IQR: 21 µg/g) was associated with −0.13 lower baseline MMSE (95% CI: −0.25, −0.004) and faster longitudinal MMSE decline (−0.016 units/year, 95% CI: −0.032, −0.0004) over 15 years. Each IQR increase in patella Pb was associated with increased risk of a MMSE score below 25 (HR=1.21, 95% CI: 0.99, 1.49; p=0.07). There were no significant associations between Pb and global cognition (both baseline and longitudinal change). Patella Pb was associated with faster longitudinal decline in Word List Total Recall in the language domain (0.014 units/year, 95% CI: −0.026, −0.001) and Word List Delayed Recall in the memory domain (0.014 units/year, 95% CI: −0.027, −0.002). We found weaker associations with tibia Pb.

    Conclusions

    Cumulative Pb exposure is associated with faster declines in MMSE and Word List Total and Delayed Recall tests. These findings support the hypothesis that Pb exposure accelerates cognitive aging.

  • Document Type:
  • Collection(s):
  • Funding:
    T42 OH008455/OH/NIOSH CDC HHS/United States
    R01 ES005257/ES/NIEHS NIH HHS/United States
    P30 ES017885/ES/NIEHS NIH HHS/United States
    K01 ES016587/ES/NIEHS NIH HHS/United States
    T32 ES007062/ES/NIEHS NIH HHS/United States
  • Supporting Files:
    No Additional Files
No Related Documents.
You May Also Like: