Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2210.160675
Personal Author:
Mesher, David; Soldan, Kate; Lehtinen, Matti; Beddows, Simon; Brisson, Marc; ... More +
Mesher, David; Soldan, Kate; Lehtinen, Matti; Beddows, Simon; Brisson, Marc; Brotherton, Julia M.L.; Chow, Eric P.F.; Cummings, Teresa; Drolet, Mélanie; Fairley, Christopher K.; Garland, Suzanne M.; Kahn, Jessica A.; Kavanagh, Kimberley; Markowitz, Lauri; Pollock, Kevin G.; Söderlund-Strand, Anna; Sonnenberg, Pam; Tabrizi, Sepehr N.; Tanton, Clare; Unger, Elizabeth; Thomas, Sara L.; Less -
Description:
We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20-24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.
Subject:
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Adolescent
Cross Protection
Female
Genotype
Humans
Immunization Programs
Papillomaviridae
Papillomavirus Infections
Papillomavirus Vaccines
Prevalence
Treatment Outcome
Young Adult

Source:
Emerg Infect Dis. 22(10):1732-1740.;
Pubmed ID:
27648688
Pubmed Central ID:
PMC5038419
Document Type:
Journal Article;
Funding:
R01 AI073713/AI/NIAID NIH HHS/United States; R01 AI104709/AI/NIAID NIH HHS/United States;
R01 AI073713/AI/NIAID NIH HHS/United States; R01 AI104709/AI/NIAID NIH HHS/United States; Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d560bc9c6b74b63c42e563f777a5f4e6169de6985ec805d9f9412e8b22354641
File Type:

Supporting Files

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  	16-0675-Techapp-s1.pdf	pdf
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