Human Papillomavirus Prevalence and Herd Immunity after Introduction of Vaccination Program, Scotland, 2009–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cameron, Ross L. ; Kavanagh, Kimberley ; Pan, Jiafeng ; Love, John ; Cuschieri, Kate ; Robertson, Chris ; Ahmed, Syed ; Palmer, Timothy ; Pollock, Kevin G.J.
• Description:
  In 2008, a national human papillomavirus (HPV) immunization program using a bivalent vaccine against HPV types 16 and 18 was implemented in Scotland along with a national surveillance program designed to determine the longitudinal effects of vaccination on HPV infection at the population level. Each year during 2009-2013, the surveillance program conducted HPV testing on a proportion of liquid-based cytology samples from women undergoing their first cervical screening test for precancerous cervical disease. By linking vaccination, cervical screening, and HPV testing data, over the study period we found a decline in HPV types 16 and 18, significant decreases in HPV types 31, 33, and 45 (suggesting cross-protection), and a nonsignificant increase in HPV 51. In addition, among nonvaccinated women, HPV types 16 and 18 infections were significantly lower in 2013 than in 2009. Our results preliminarily indicate herd immunity and sustained effectiveness of the bivalent vaccine on virologic outcomes at the population level.
• Subjects:
  Adult Cross Protection Female Humans Immunity, Herd Immunization Programs Papillomaviridae Papillomavirus Infections Papillomavirus Vaccines Prevalence Vaccination Young Adult

  More +
• Source:
  Emerg Infect Dis. 22(1):56-64.
• Pubmed ID:
  26692336
• Pubmed Central ID:
  PMC4696690
• Document Type:
  Journal Article
• Place as Subject:
  Scotland
• Volume:
  22
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b440c9eba02dad01536c70a7f780d6a2dc05aa36af9fd76f4702191a9bf9f283
• Download URL:
  https://stacks.cdc.gov/view/cdc/37270/cdc_37270_DS1.pdf
• File Type:
  [PDF - 527.22 KB ]