Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Fitzgerald, Felicity; Naveed, Asad; Wing, Kevin; Gbessay, Musa; Ross, J.C.G.; Checchi, Francesco; Youkee, Daniel; Jalloh, Mohammed Boie; Baion, David; Mustapha, Ayeshatu; Jah, Hawanatu; Lako, Sandra; Oza, Shefali; Boufkhed, Sabah; Feury, Reynold; Bielicki, Julia A.; Gibb, Diana M.; Klein, Nigel; Sahr, Foday; Yeung, Shunmay

doi:10.3201/eid2210.160579

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Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Published Date:

Oct 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2210.160579 New Site Icon

Source:

Emerg Infect Dis. 22(10):1769-1777.

[PDF - 1.55 MB]

Details:

Personal Authors:

Fitzgerald, Felicity ; Naveed, Asad ; Wing, Kevin ; Gbessay, Musa ; Ross, J.C.G. ; ... More ▼

Keywords:

[+]

Pubmed ID:

27649367

Pubmed Central ID:

PMC5038433

Description:

Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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