Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2210.160579
Personal Author:
Fitzgerald, Felicity ; Naveed, Asad ; Wing, Kevin ; Gbessay, Musa ; Ross, J.C.G. ; ... More +
Fitzgerald, Felicity ; Naveed, Asad ; Wing, Kevin ; Gbessay, Musa ; Ross, J.C.G. ; Checchi, Francesco ; Youkee, Daniel ; Jalloh, Mohammed Boie ; Baion, David ; Mustapha, Ayeshatu ; Jah, Hawanatu ; Lako, Sandra ; Oza, Shefali ; Boufkhed, Sabah ; Feury, Reynold ; Bielicki, Julia A. ; Gibb, Diana M. ; Klein, Nigel ; Sahr, Foday ; Yeung, Shunmay Less -
Description:
Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014-2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus-positive children 2 days-12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.
Subject:
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Child Ebolavirus Hemorrhagic Fever, Ebola Research
Source:
Emerg Infect Dis. 22(10):1769-1777.
Pubmed ID:
27649367
Pubmed Central ID:
PMC5038433
Document Type:
Journal Article
Place as Subject:
Sierra Leone
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6a92a426b55a9b858d4576afd00e7dfd3fb2f54aa44a2c686772375a63060446
Download URL:
https://stacks.cdc.gov/view/cdc/42757/cdc_42757_DS1.pdf
File Type:

Supporting Files

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