Development of a Pediatric Ebola Predictive Score, Sierra Leone

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fitzgerald, Felicity ; Wing, Kevin ; Naveed, Asad ; Gbessay, Musa ; Ross, J.C.G. ; Checchi, Francesco ; Youkee, Daniel ; Jalloh, Mohamed Boie ; Baion, David E. ; Mustapha, Ayeshatu ; Jah, Hawanatu ; Lako, Sandra ; Oza, Shefali ; Boufkhed, Sabah ; Feury, Reynold ; Bielicki, Julia ; Williamson, Elizabeth ; Gibb, Diana M. ; Klein, Nigel ; Sahr, Foday ; Yeung, Shunmay
• Description:
  We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%-90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required.
• Subjects:
  Adolescent Child Child, Preschool Cohort Studies Disease Outbreaks Ebolavirus Hemorrhagic Fever, Ebola Humans Infant Retrospective Studies Risk Factors

  More +
• Source:
  Emerg Infect Dis. 24(2):311-319.
• Pubmed ID:
  29350145
• Pubmed Central ID:
  PMC5782873
• Document Type:
  Journal Article
• Place as Subject:
  Sierra Leone
• Volume:
  24
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2167e92750c09ddf5037d5a8b034a2ee7f756d088d4f42ed264342b15f6dc341
• Download URL:
  https://stacks.cdc.gov/view/cdc/51381/cdc_51381_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]