Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2210.160468
Personal Author:
Kretz, Cecilia B. ; Retchless, Adam C. ; Sidikou, Fati ; Issaka, Bassira ; Ousmane, Sani ; ... More +
Kretz, Cecilia B. ; Retchless, Adam C. ; Sidikou, Fati ; Issaka, Bassira ; Ousmane, Sani ; Schwartz, Stephanie ; Tate, Ashley H. ; Pana, Assimawè ; Njanpop-Lafourcade, Berthe-Marie ; Nzeyimana, Innocent ; Nse, Ricardo Obama ; Deghmane, Ala-Eddine ; Hong, Eva ; Brynildsrud, Ola Brønstad ; Novak, Ryan T. ; Meyer, Sarah A. ; Oukem-Boyer, Odile Ouwe Missi ; Ronveaux, Olivier ; Caugant, Dominique A. ; Taha, Muhamed-Kheir ; Wang, Xin ; Less -
Corporate Authors:
Niger Response Team ;
Description:
In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis. All NmC isolates had sequence type 10217, which caused the outbreaks in Nigeria during 2013-2014 and for which a clonal complex has not yet been defined. The NmC isolates from Niger were substantially different from other NmC isolates collected globally. All NmW isolates belonged to clonal complex 11 and were closely related to the isolates causing recent outbreaks in Africa.
Subject:
[+]
Bacteria
Meningitis Belt
Meningococcal Meningitis
Neisseria Meningitidis Serogroup C
Niger
Research
Whole-Genome Characterization Of Epidemic Neisseria Meningitidis Serogroup C And Resurging Serogroup W, Niger, 2015
Whole-genome Sequencing

Source:
Emerg Infect Dis. 22(10):1762-1768. ;
Pubmed ID:
27649262
Pubmed Central ID:
PMC5038424
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d377a298c571aad0ecf6fd839b8c4003cfd6d2f3f8a0841c4f13f7cae7a6a850
File Type:

Supporting Files

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