Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015

Kretz, Cecilia B.; Retchless, Adam C.; Sidikou, Fati; Issaka, Bassira; Ousmane, Sani; Schwartz, Stephanie; Tate, Ashley H.; Pana, Assimawè; Njanpop-Lafourcade, Berthe-Marie; Nzeyimana, Innocent; Nse, Ricardo Obama; Deghmane, Ala-Eddine; Hong, Eva; Brynildsrud, Ola Brønstad; Novak, Ryan T.; Meyer, Sarah A.; Oukem-Boyer, Odile Ouwe Missi; Ronveaux, Olivier; Caugant, Dominique A.; Taha, Muhamed-Kheir; Wang, Xin

doi:10.3201/eid2210.160468

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015

Published Date:

Oct 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2210.160468 New Site Icon

Source:

Emerg Infect Dis. 22(10):1762-1768.

[PDF-1.53 MB]

Details:

Personal Authors:

Kretz, Cecilia B. ; Retchless, Adam C. ; Sidikou, Fati ; Issaka, Bassira ; Ousmane, Sani ; ... More ▼

Corporate Authors:

Niger Response Team

Keywords:

[+]

Pubmed ID:

27649262

Pubmed Central ID:

PMC5038424

Description:

In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis. All NmC isolates had sequence type 10217, which caused the outbreaks in Nigeria during 2013-2014 and for which a clonal complex has not yet been defined. The NmC isolates from Niger were substantially different from other NmC isolates collected globally. All NmW isolates belonged to clonal complex 11 and were closely related to the isolates causing recent outbreaks in Africa.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	16-0468-F1.gif	image/gif
	16-0468-F1.jpg	image/jpeg
	16-0468-F2.gif	image/gif
	16-0468-F2.jpg	image/jpeg
	16-0468-F3.gif	image/gif
	16-0468-F3.jpg	image/jpeg
	16-0468-Techapp-s1.pdf	application/pdf
	16-0468.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Phylogenetic relationships and regional spread of meningococcal strains in the meningitis belt, 2011–2016

Personal Author:

Topaz, Nadav; Caugant, Dominique A.; Taha, Muhamed-Kheir; Brynildsrud, Ola Brønstad; Debech, Nadia; Hong, Eva; Deghmane, Ala-Eddine; Ouédraogo, Rasmata; Ousmane, Sani; Gamougame, Kadidja; Njanpop-Lafourcade, Berthe-Marie; Diarra, Seydou; Fox, LeAnne M.; Wang, Xin;

Published:

March 04 2019

Source:

EBioMedicine. 2019; 41:488-496

Description:

Background : Historically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogro...

File Type:

[PDF - 1.31 MB]
Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data

Personal Author:

Sidikou, Fati; Zaneidou, Maman; Alkassoum, Ibrahim; Schwartz, Stephanie; Issaka, Bassira; Obama, Ricardo; Lingani, Clement; Tate, Ashley; Ake, Flavien; Sakande, Souleymane; Ousmane, Sani; Zanguina, Jibir; Seidou, Issaka; Nzeyimana, Innocent; Mounkoro, Didier; Abodji, Oubote; Wang, Xin; Taha, Muhamed-Kheir; Moulia-Pelat, Jean Paul; Pana, Assimawe; Kadade, Goumbi; Ronveaux, Olivier; Novak, Ryan; Oukem-Boyer, Odile Ouwe Missi; Meyer, Sarah;

Published:

Aug 23 2016

Source:

Lancet Infect Dis. 16(11):1288-1294.

Description:

Background : To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidem...

File Type:

[PDF - 320.91 KB]
The Establishment and Diversification of Epidemic-Associated Serogroup W Meningococcus in the African Meningitis Belt, 1994 to 2012

Personal Author:

Retchless, Adam C.; Hu, Fang; Ouédraogo, Abdoul-Salam; Diarra, Seydou; Knipe, Kristen; Sheth, Mili; Rowe, Lori A.; Sangaré, Lassana; Ky Ba, Absetou; Ouangraoua, Soumeya; Batra, Dhwani; Novak, Ryan T.; Ouédraogo Traoré, Rasmata; Wang, Xin;

Published:

2016 Nov-Dec

Source:

mSphere. 2016; 1(6).

Description:

Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to...

File Type:

[PDF - 410.71 KB]
High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine

Personal Author:

McNamara, Lucy A.; Topaz, Nadav; Wang, Xin; Hariri, Susan; Fox, LeAnne; MacNeil, Jessica R.;

Published:

Jul 14 2017

Source:

MMWR Morb Mortal Wkly Rep. 66(27):734-737.

Description:

Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of meningococcal disease (1). Administration of meningococcal vaccines is recommended for patient...

File Type:

[PDF - 234.04 KB]
DBD bulletin ; issue 17, winter 2015

Corporate Author:

National Center for Immunization and Respiratory Diseases (U.S.). Division of Bacterial Diseases.

Published:

winter 2015

Series:

DBD bulletin ; issue 17

Description:

dbd-bulletin-winter2015.pdf

File Type:

[PDF - 4.29 MB]