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Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015
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    Topaz, Nadav; Caugant, Dominique A.; Taha, Muhamed-Kheir; Brynildsrud, Ola Brønstad; Debech, Nadia; Hong, Eva; Deghmane, Ala-Eddine; Ouédraogo, Rasmata; Ousmane, Sani; Gamougame, Kadidja; Njanpop-Lafourcade, Berthe-Marie; Diarra, Seydou; Fox, LeAnne M.; Wang, Xin;
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    EBioMedicine. 2019; 41:488-496
    Description:
    BackgroundHistorically, the major cause of meningococcal epidemics in the meningitis belt of sub-Saharan Africa has been Neisseria meningitidis serogroup A (NmA), but the incidence has been substantially reduced since the introduction of a serogroup ...
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  2. Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data
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    Sidikou, Fati; Zaneidou, Maman; Alkassoum, Ibrahim; Schwartz, Stephanie; Issaka, Bassira; Obama, Ricardo; Lingani, Clement; Tate, Ashley; Ake, Flavien; Sakande, Souleymane; Ousmane, Sani; Zanguina, Jibir; Seidou, Issaka; Nzeyimana, Innocent; Mounkoro, Didier; Abodji, Oubote; Wang, Xin; Taha, Muhamed-Kheir; Moulia-Pelat, Jean Paul; Pana, Assimawe; Kadade, Goumbi; Ronveaux, Olivier; Novak, Ryan; Oukem-Boyer, Odile Ouwe Missi; Meyer, Sarah;
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    Aug 23 2016
    Source:
    Lancet Infect Dis. 16(11):1288-1294.
    Description:
    BackgroundTo combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic ...
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  3. The Establishment and Diversification of Epidemic-Associated Serogroup W Meningococcus in the African Meningitis Belt, 1994 to 2012
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    Retchless, Adam C.; Hu, Fang; Ouédraogo, Abdoul-Salam; Diarra, Seydou; Knipe, Kristen; Sheth, Mili; Rowe, Lori A.; Sangaré, Lassana; Ky Ba, Absetou; Ouangraoua, Soumeya; Batra, Dhwani; Novak, Ryan T.; Ouédraogo Traoré, Rasmata; Wang, Xin;
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    2016 Nov-Dec
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    mSphere. 2016; 1(6).
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    Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to...
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  4. High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine
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    McNamara, Lucy A.; Topaz, Nadav; Wang, Xin; Hariri, Susan; Fox, LeAnne; MacNeil, Jessica R.;
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    Jul 14 2017
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    MMWR Morb Mortal Wkly Rep. 66(27):734-737.
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    Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of meningococcal disease (1). Administration of meningococcal vaccines is recommended for patient...
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  5. Population structure of invasive Neisseria meningitidis in the United States, 2011–15☆
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    Potts, Caelin C.; Joseph, Sandeep j.; Chang, How-Yi; Chen, Alexander; Vuong, jeni; Hu, Fang; jenkins, Laurel T.; Schmink, Susanna; Blain, Amy; MacNeil, Jessica R.; Harrison, Lee H.; Wang, Xin;
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    June 30 2018
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    J Infect. 77(5):427-434
    Description:
    Objectives:Meningococcal conjugate vaccines (MenACWY) were licensed in the United States in 2005. We assessed the population structure of invasive Neisseria meningitidis (Nm) ten years after recommended use of MenACWY among adolescents.Methods:Mening...
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