Hepatocellular Carcinoma Risk in Hepatitis B Virus Infected Alaska Native Children and Young Adults: Retrospective Cohort Analysis

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Gounder, Prabhu P. ; Bulkow, Lisa R. ; Snowball, Mary ; Negus, Susan ; Spradling, Philip R. ; McMahon, Brian J.
• Description:
  Objectives
  
  To evaluate the hepatocellular carcinoma (HCC) risk in hepatitis B virus (HBV)-infected Alaska Native (AN) children and young adults.
  
  Study design
  
  Retrospective analysis of a population-based cohort of HBV-infected AN persons followed during 1982–2012. All HBV-infected persons were offered HCC screening regardless of age using alpha-fetoprotein (AFP) every 6 months; persons with an elevated AFP or persons at high-risk for HCC, such as cirrhosis, family history of HCC, were offered ultrasound. We calculated the HCC incidence/1,000 person-years from date of cohort entry until death, diagnosis of HCC, or attaining the age of 40 years (males) or 50 years (females).
  
  Results
  
  We followed 1083 HBV-infected persons (56% male) comprising 5 genotypes (A2 [12.5%], B6 [1.7%], C [5.3%], D [49.7%], F1 [18.6%], unknown [12.4%]) for a median of 23.4 years/person. We observed 22 HCC cases (incidence/1,000 person-years follow-up: 1.0); 19 HCC cases among persons with genotype F1. There was no significant difference in HCC incidence between males (1.4) and females (0.6). The HCC incidence was significantly higher for persons with genotype F1 (4.4) compared with genotype A2 (0.4) and D (0.2) and remained higher among persons with HBV genotype F1 excluding persons with HCC family history/cirrhosis (1.9).
  
  Conclusions
  
  HBV genotype F1-infected AN children and young adults are at high risk for HCC and should receive HCC surveillance. For HBV-infected males and females age <40 and <50 years, respectively, in regions of the world with a high genotype F prevalence, testing/confirming genotype F can identify persons who could benefit from HCC surveillance.
  
  
• Subjects:
  Adult Alaska Natives Alpha-Fetoproteins Carcinoma, Hepatocellular Child Cohort Studies Female Genotype Hepatitis B Hepatitis B Virus Humans Incidence Liver Neoplasms Male Retrospective Studies Risk Factors Young Adult

  More +
• Source:
  J Pediatr. 178:206-213.
• Pubmed ID:
  27590612
• Pubmed Central ID:
  PMC5085839
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; U01 PS004113/PS/NCHHSTP CDC HHS/United States
• Volume:
  178
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cf6cc7b6bdd356c0cad123b13d22379c42bcf843710838061c17cf2f91061486
• Download URL:
  https://stacks.cdc.gov/view/cdc/42698/cdc_42698_DS1.pdf
• File Type:
  [PDF - 258.25 KB ]