Details:

Alternative Title:
Liver Int
Personal Author:
Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; ... More +
Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; Negus, Susan ; Snowball, Mary ; McMahon, Brian J. Less -
Description:
Background & Aims

Most regions of the world have <3 co-circulating hepatitis B virus (HBV) genotypes, which limits direct comparisons of hepatocellular carcinoma (HCC) risk among HBV-infected persons by genotype. We evaluated HCC incidence by HBV genotype in a cohort of Alaska Native (AN) persons where 5 HBV genotypes (A, B, C, D, F) have been identified.

Methods

Our cohort comprised AN persons with chronic HBV infection identified during 1983–2012 who consented to participate in the study. Cohort persons were offered annual hepatitis B e antigen (HBeAg) testing and semiannual HCC screening. We developed a logistic regression model to compare HCC risk by genotype, adjusting for age, sex, region, and HBeAg status.

Results

Among the 1,235 consenting study participants, 711 (57.6%) were male, 510 (41.3%) were HBeAg positive at cohort entry, and 43 (3.5%) developed HCC. The HBV genotype was known for 1,142 (92.5%) persons (13.5% A, 3.9% B, 6.7% C, 56.9% D, 19.0% F). The HCC incidence/1,000 person-years of follow-up for genotypes A, B, C, D, and F was 1.3, 0, 5.5, 0.4, and 4.2, respectively. Compared with persons with HBV genotype B/D infection, the HCC risk was higher for persons with genotypes A (adjusted odds ratio [aOR]: 3.9, 95% CI: 1.14–13.74), C (aOR: 16.3, 95% CI: 5.20–51.11), and F (aOR: 13.9, 95% CI: 5.30–36.69).

Conclusion

HBV genotype is independently associated with HCC risk. AN persons with genotypes A, C, and F are at higher risk compared with genotypes B or D.


Subjects:
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Adult Aged Alaskan Natives Article Carcinoma, Hepatocellular Epidemiology Female Genomics Genotype Hepatitis B, Chronic Hepatitis B E Antigens Hepatitis B Virus Humans Incidence Liver Cancer Liver Neoplasms Logistic Models Male Middle Aged Native American Odds Ratio Retrospective Studies Risk Factors United States
Source:
Liver Int. 36(10):1507-1515
Pubmed ID:
27009849
Pubmed Central ID:
PMC5021564
Document Type:
Journal Article
Funding:
U01 PS004113/PS/NCHHSTP CDC HHSUnited States/ ; U01PS004113/ACL/ACL HHSUnited States/
U01 PS004113/PS/NCHHSTP CDC HHSUnited States/ ; U01PS004113/ACL/ACL HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f65326b42bd8869316b1ee8b3b4e37f0f30f5306137bfb79f20c9082ea2e430e
Download URL:
https://stacks.cdc.gov/view/cdc/41329/cdc_41329_DS1.pdf
File Type:

Supporting Files

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