Details:

Alternative Title:
Liver Int
Publisher's site:
http://dx.doi.org/10.1111/liv.13129
Personal Author:
Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; ... More +
Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; Negus, Susan ; Snowball, Mary ; McMahon, Brian J. Less -
Description:
Background & Aims

Most regions of the world have <3 co-circulating hepatitis B virus (HBV) genotypes, which limits direct comparisons of hepatocellular carcinoma (HCC) risk among HBV-infected persons by genotype. We evaluated HCC incidence by HBV genotype in a cohort of Alaska Native (AN) persons where 5 HBV genotypes (A, B, C, D, F) have been identified.

Methods

Our cohort comprised AN persons with chronic HBV infection identified during 1983–2012 who consented to participate in the study. Cohort persons were offered annual hepatitis B e antigen (HBeAg) testing and semiannual HCC screening. We developed a logistic regression model to compare HCC risk by genotype, adjusting for age, sex, region, and HBeAg status.

Results

Among the 1,235 consenting study participants, 711 (57.6%) were male, 510 (41.3%) were HBeAg positive at cohort entry, and 43 (3.5%) developed HCC. The HBV genotype was known for 1,142 (92.5%) persons (13.5% A, 3.9% B, 6.7% C, 56.9% D, 19.0% F). The HCC incidence/1,000 person-years of follow-up for genotypes A, B, C, D, and F was 1.3, 0, 5.5, 0.4, and 4.2, respectively. Compared with persons with HBV genotype B/D infection, the HCC risk was higher for persons with genotypes A (adjusted odds ratio [aOR]: 3.9, 95% CI: 1.14–13.74), C (aOR: 16.3, 95% CI: 5.20–51.11), and F (aOR: 13.9, 95% CI: 5.30–36.69).

Conclusion

HBV genotype is independently associated with HCC risk. AN persons with genotypes A, C, and F are at higher risk compared with genotypes B or D.


Subject:
[+]
Aged Alaska Natives Carcinoma, Hepatocellula /ethnology Female Genotype Hepatitis B, Chronic Hepatitis B, Chronic/ethnology Hepatitis B E Antigens Hepatitis B Virus Humans Incidence Liver Neoplasms/ethnology Logistic Models Male Middle Aged Odds Ratio Retrospective Studies
Source:
Liver Int. 36(10):1507-1515.
Pubmed ID:
27009849
Pubmed Central ID:
PMC5021564
Document Type:
Journal Article
Funding:
U01 PS004113/PS/NCHHSTP CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f65326b42bd8869316b1ee8b3b4e37f0f30f5306137bfb79f20c9082ea2e430e
Download URL:
https://stacks.cdc.gov/view/cdc/41329/cdc_41329_DS1.pdf
File Type:

Supporting Files

• 	nihms780396.nxml	xml
  	nihms780396f1.gif	gif
  	nihms780396f1.jpg	jpeg
  	nihms780396f2.gif	gif
  	nihms780396f2.jpg	jpeg

More +