Incidence of Hepatocellular Carcinoma According to Hepatitis B Virus Genotype in Alaska Native People

Details

• Alternative Title:
  Liver Int
• Personal Author:
  Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; Negus, Susan ; Snowball, Mary ; McMahon, Brian J.
• Description:
  Background & Aims ; Most regions of the world have <3 co-circulating hepatitis B virus (HBV) genotypes, which limits direct comparisons of hepatocellular carcinoma (HCC) risk among HBV-infected persons by genotype. We evaluated HCC incidence by HBV genotype in a cohort of Alaska Native (AN) persons where 5 HBV genotypes (A, B, C, D, F) have been identified. ; Methods ; Our cohort comprised AN persons with chronic HBV infection identified during 1983–2012 who consented to participate in the study. Cohort persons were offered annual hepatitis B e antigen (HBeAg) testing and semiannual HCC screening. We developed a logistic regression model to compare HCC risk by genotype, adjusting for age, sex, region, and HBeAg status. ; Results ; Among the 1,235 consenting study participants, 711 (57.6%) were male, 510 (41.3%) were HBeAg positive at cohort entry, and 43 (3.5%) developed HCC. The HBV genotype was known for 1,142 (92.5%) persons (13.5% A, 3.9% B, 6.7% C, 56.9% D, 19.0% F). The HCC incidence/1,000 person-years of follow-up for genotypes A, B, C, D, and F was 1.3, 0, 5.5, 0.4, and 4.2, respectively. Compared with persons with HBV genotype B/D infection, the HCC risk was higher for persons with genotypes A (adjusted odds ratio aOR: 3.9, 95% CI: 1.14–13.74), C (aOR: 16.3, 95% CI: 5.20–51.11), and F (aOR: 13.9, 95% CI: 5.30–36.69). ; Conclusion ; HBV genotype is independently associated with HCC risk. AN persons with genotypes A, C, and F are at higher risk compared with genotypes B or D.
• Keywords:
  • liver cancer
  • risk factors
  • Native American
  • epidemiology
  • genomics
  • Adult
  • Aged
  • Alaska Natives
  • Carcinoma, Hepatocellular
  • Female
  More +
• Source:
  Liver Int. 36(10):1507-1515
• Pubmed ID:
  27009849
• Pubmed Central ID:
  PMC5021564
• Document Type:
  Journal Article
• Funding:
  U01 PS004113/PS/NCHHSTP CDC HHSUnited States/ ; U01PS004113/ACL/ACL HHSUnited States/
• Volume:
  36
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/41329/cdc_41329_DS1.pdf
• File Type:
  [PDF - 1.32 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f65326b42bd8869316b1ee8b3b4e37f0f30f5306137bfb79f20c9082ea2e430e