Incidence of Hepatocellular Carcinoma According to Hepatitis B Virus Genotype in Alaska Native People

Details

• Alternative Title:
  Liver Int
• Personal Author:
  Ching, Lance K. ; Gounder, Prabhu P. ; Bulkow, Lisa ; Spradling, Philip R. ; Bruce, Michael ; Negus, Susan ; Snowball, Mary ; McMahon, Brian J.
• Description:
  Background & Aims
  
  Most regions of the world have <3 co-circulating hepatitis B virus (HBV) genotypes, which limits direct comparisons of hepatocellular carcinoma (HCC) risk among HBV-infected persons by genotype. We evaluated HCC incidence by HBV genotype in a cohort of Alaska Native (AN) persons where 5 HBV genotypes (A, B, C, D, F) have been identified.
  
  Methods
  
  Our cohort comprised AN persons with chronic HBV infection identified during 1983–2012 who consented to participate in the study. Cohort persons were offered annual hepatitis B e antigen (HBeAg) testing and semiannual HCC screening. We developed a logistic regression model to compare HCC risk by genotype, adjusting for age, sex, region, and HBeAg status.
  
  Results
  
  Among the 1,235 consenting study participants, 711 (57.6%) were male, 510 (41.3%) were HBeAg positive at cohort entry, and 43 (3.5%) developed HCC. The HBV genotype was known for 1,142 (92.5%) persons (13.5% A, 3.9% B, 6.7% C, 56.9% D, 19.0% F). The HCC incidence/1,000 person-years of follow-up for genotypes A, B, C, D, and F was 1.3, 0, 5.5, 0.4, and 4.2, respectively. Compared with persons with HBV genotype B/D infection, the HCC risk was higher for persons with genotypes A (adjusted odds ratio aOR: 3.9, 95% CI: 1.14–13.74), C (aOR: 16.3, 95% CI: 5.20–51.11), and F (aOR: 13.9, 95% CI: 5.30–36.69).
  
  Conclusion
  
  HBV genotype is independently associated with HCC risk. AN persons with genotypes A, C, and F are at higher risk compared with genotypes B or D.
• Keywords:
  • liver cancer
  • risk factors
  • Native American
  • epidemiology
  • genomics
  • Adult
  • Aged
  • Alaska Natives
  • Carcinoma, Hepatocellular
  • Female
  More +
• Source:
  Liver Int. 36(10):1507-1515
• Pubmed ID:
  27009849
• Pubmed Central ID:
  PMC5021564
• Document Type:
  Journal Article
• Funding:
  U01 PS004113/PS/NCHHSTP CDC HHSUnited States/ ; U01PS004113/ACL/ACL HHSUnited States/
• Volume:
  36
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/41329/cdc_41329_DS1.pdf
• File Type:
  [PDF - 1.32 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f65326b42bd8869316b1ee8b3b4e37f0f30f5306137bfb79f20c9082ea2e430e