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Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study
  • Published Date:
    May 09 2016
  • Source:
    Int J Cancer. 139(5):1081-1090.


Public Access Version Available on: September 01, 2017 information icon
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Details:
  • Pubmed ID:
    27098183
  • Pubmed Central ID:
    PMC4911232
  • Description:
    Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial CRC diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow-up of 6.6 years, 142 (1.81%) metachronous CRCs were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1,000 person-years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR = 2.73; 95% CI: 1.30-5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR = 4.16; 95% CI: 2.80-6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC.

  • Document Type:
  • Collection(s):
  • Funding:
    HHSN261201000140C/CA/NCI NIH HHS/United States
    U01 CA074799/CA/NCI NIH HHS/United States
    HHSN261201000035C/CA/NCI NIH HHS/United States
    U24 CA074783/CA/NCI NIH HHS/United States
    N01 CN067009/CN/NCI NIH HHS/United States
    U24 CA074794/CA/NCI NIH HHS/United States
    N01PC35137/CA/NCI NIH HHS/United States
    U24 CA074806/CA/NCI NIH HHS/United States
    HHSN261201300009C/CA/NCI NIH HHS/United States
    U24 CA097735/CA/NCI NIH HHS/United States
    U01 CA074794/CA/NCI NIH HHS/United States
    HHSN261201300012I/CA/NCI NIH HHS/United States
    N01PC35142/CA/NCI NIH HHS/United States
    HHSN261201300021C/CA/NCI NIH HHS/United States
    HHSN261201000035I/CA/NCI NIH HHS/United States
    HHSN261201000034C/CA/NCI NIH HHS/United States
    U01 CA097735/CA/NCI NIH HHS/United States
    UM1 CA167551/CA/NCI NIH HHS/United States
    U58 DP003862/DP/NCCDPHP CDC HHS/United States
    U01 CA074783/CA/NCI NIH HHS/United States
    U24 CA074799/CA/NCI NIH HHS/United States
    U01 CA074806/CA/NCI NIH HHS/United States
    U24 CA074800/CA/NCI NIH HHS/United States
    HHSN261201000121C/CP/NCI NIH HHS/United States
    U01 CA074800/CA/NCI NIH HHS/United States
  • Supporting Files:
    No Additional Files
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