The Penn Parkinson’s Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson’s disease

Details

• Alternative Title:
  Parkinsonism Relat Disord
• Personal Author:
  Brennan, Laura ; Siderowf, Andrew ; Rubright, Jonathan D. ; Rick, Jacqueline ; Dahodwala, Nabila ; Duda, John E. ; Hurtig, Howard ; Stern, Matthew ; Xie, Sharon X. ; Rennert, Lior ; Karlawish, Jason ; Shea, Judy A. ; Trojanowski, John Q. ; Weintraub, Daniel
• Description:
  Introduction
  
  To describe the psychometric properties of the Penn Parkinson’s Daily Activities Questionnaire-15 (PDAQ-15), a 15-item measure of cognitive instrumental activities of daily living for Parkinson’s disease (PD) patients derived from the original 50-item PDAQ.
  
  Methods
  
  PDAQ-15 items were chosen by expert consensus. Knowledgeable informants of PD participants (n=161) completed the PDAQ-15. Knowledgeable informants were defined as an individual having regular contact with the PD participant. PD participants were assigned a diagnosis of normal cognition, mild cognitive impairment, or dementia based on expert consensus.
  
  Results
  
  PDAQ-15 scores correlated strongly with global cognition (Dementia Rating Scale-2, r=0.71, p<0.001) and a performance-based functional measure (Direct Assessment of Functional Status, r=0.83; p<0.001). PDAQ-15 scores accurately discriminated between non-demented PD participants (normal cognition/mild cognitive impairment) and PD with dementia (ROC curve area=0.91), with and without any cognitive impairment (normal cognition versus mild cognitive impairment/dementia, ROC curve area=0.85) and between participants with mild cognitive impairment and dementia (ROC curve area=0.84).
  
  Conclusions
  
  The PDAQ-15 shows good discriminant validity across cognitive stages, correlates highly with global cognitive performance, and appears suitable to assess daily cognitive functioning in PD.
  
  
• Subjects:
  Activities Of Daily Living Aged Cognition Disorders Female Humans Male Parkinson Disease Psychometrics Surveys And Questionnaires
• Source:
  Parkinsonism Relat Disord. 25:21-26.
• Pubmed ID:
  26923524
• Pubmed Central ID:
  PMC4818172
• Document Type:
  Journal Article
• Funding:
  P30 AG010124/AG/NIA NIH HHS/United States ; T32 MH065218/MH/NIMH NIH HHS/United States ; P01 AG017586/AG/NIA NIH HHS/United States ; U01 AG024904/AG/NIA NIH HHS/United States ; R01 AG025152/AG/NIA NIH HHS/United States ; R01 NS065087/NS/NINDS NIH HHS/United States ; U48 DP005053/DP/NCCDPHP CDC HHS/United States ; R01 AG038440/AG/NIA NIH HHS/United States ; P50 NS053488/NS/NINDS NIH HHS/United States ; K23 AG034236/AG/NIA NIH HHS/United States ; U01 AG010483/AG/NIA NIH HHS/United States ; NS-053488/NS/NINDS NIH HHS/United States ; U01 AG029213/AG/NIA NIH HHS/United States
• Volume:
  25
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d5c02458167f57af81137c5d4a04771cfb83a063f510b4cf242f258fd95aabc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/42102/cdc_42102_DS1.pdf
• File Type:
  [PDF - 757.06 KB ]