Angiogenesis genes, dietary oxidative balance, and breast cancer risk and progression: The Breast Cancer Health Disparities Study

Details

• Alternative Title:
  Int J Cancer
• Personal Author:
  Slattery, Martha L. ; John, Esther M. ; Torres-Mejia, Gabriela ; Lundgreen, Abbie ; Lewinger, Juan Pablo ; Stern, Mariana ; Hines, Lisa ; Baumgartner, Kathy B. ; Giuliano, Anna R. ; Wolff, Roger K.
• Description:
  Angiogenesis is essential for tumor development and progression. Genetic variation in angiogenesis-related genes may influence breast carcinogenesis. We evaluated dietary factors associated with oxidative balance, DDIT4 (one SNP), FLT1 (35 SNPs), HIF1A (four SNPs), KDR (19 SNPs), MPO (one SNP), NOS2A (15 SNPs), TEK (40 SNPs) and VEGFA (eight SNPs) and breast cancer risk among Hispanic (2,111 cases and 2,597 controls) and non-Hispanic white (1,481 cases and 1,586 controls) women in the Breast Cancer Health Disparities Study. Adaptive rank truncated product (ARTP) analysis was used to determine gene and pathway significance with breast cancer. TEK was associated with breast cancer overall (pARTP = 0.03) and with breast cancer survival (pARTP = 0.01). KDR was of borderline significance overall (pARTP = 0.07), although significantly associated with breast cancer in both low and intermediate Native American (NA) ancestry groups (pARTP = 0.02) and estrogen receptor (ER)+/progesterone receptor (PR)- tumor phenotype (pARTP = 0.008). Both VEGFA and NOS2A were associated with ER-/PR- tumor phenotype (pARTP = 0.01 and pARTP = 0.04, respectively). FLT1 was associated with breast cancer survival among those with low NA ancestry (pARTP = 0.009). With respect to diet, having a higher dietary oxidative balance score (DOBS) was significantly associated with lower breast cancer risk [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.64-0.84], with the strongest associations observed for women with the highest NA ancestry (OR 0.44, 95% CI 0.30-0.65). We observed few interactions between DOBS and angiogenesis-related genes. Our data suggest that dietary factors and genetic variation in angiogenesis-related genes contribute to breast cancer carcinogenesis.
• Subjects:
  Adult Aged Breast Neoplasms Case-Control Studies Diet Disease Progression Female Humans Hypoxia-Inducible Factor 1, Alpha Subunit Middle Aged Neovascularization, Pathologic Nitric Oxide Synthase Type II Oxidative Stress Peroxidase Polymorphism, Single Nucleotide Transcription Factors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-2

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• Keywords:
  Antioxidants Breast Cancer Diet FLT1 Hispanic KDR NOS2A Survival TEK VEGFA
• Source:
  Int J Cancer. 134(3):629-644
• Pubmed ID:
  23832257
• Pubmed Central ID:
  PMC3830596
• Document Type:
  Journal Article
• Funding:
  CA77305/CA/NCI NIH HHSUnited States/ ; CA078682/CA/NCI NIH HHSUnited States/ ; R01 CA078552/CA/NCI NIH HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; R01 CA078762/CA/NCI NIH HHSUnited States/ ; R01 CA140002/CA/NCI NIH HHSUnited States/ ; R01 CA063446/CA/NCI NIH HHSUnited States/ ; CA078552/CA/NCI NIH HHSUnited States/ ; CA078802/CA/NCI NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA078802/CA/NCI NIH HHSUnited States/ ; R01 CA078682/CA/NCI NIH HHSUnited States/ ; CA14002/CA/NCI NIH HHSUnited States/ ; CA078762/CA/NCI NIH HHSUnited States/
• Volume:
  134
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2c69f5865321bf5b592a2aed0b0b2313f96c0ce0f272243075ee899272987b9c
• Download URL:
  https://stacks.cdc.gov/view/cdc/41924/cdc_41924_DS1.pdf
• File Type:
  [PDF - 161.79 KB ]