Active and Passive Cigarette Smoking and Mortality among Hispanic and non-Hispanic White Women Diagnosed with Invasive Breast Cancer
Published Date:Aug 28 2015
Source:Ann Epidemiol. 25(11):824-831.
Body Mass Index
Cause Of Death
European Continental Ancestry Group
Native American Ancestry
Surveys And Questionnaires
Tobacco Smoke Pollution
Pubmed Central ID:PMC4609618
Funding:CA77305/CA/NCI NIH HHS/United States
R01 CA63446/CA/NCI NIH HHS/United States
HHSN261201000036C/PHS HHS/United States
CA078682/CA/NCI NIH HHS/United States
R01 CA078552/CA/NCI NIH HHS/United States
R01 CA078762/CA/NCI NIH HHS/United States
U58 DP000807/DP/NCCDPHP CDC HHS/United States
R01 CA078802/CA/NCI NIH HHS/United States
R01 CA078682/CA/NCI NIH HHS/United States
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States
R01 CA140002/CA/NCI NIH HHS/United States
HHSN261201000036/CA/NCI NIH HHS/United States
CA078552/CA/NCI NIH HHS/United States
N01-PC-67000/PC/NCI NIH HHS/United States
CA14002/CA/NCI NIH HHS/United States
CA078762/CA/NCI NIH HHS/United States
CA63446/CA/NCI NIH HHS/United States
CA078802/CA/NCI NIH HHS/United States
Women who smoke at breast cancer diagnosis have higher risk of breast cancer-specific and all-cause mortality than non-smokers; however, differences by ethnicity or prognostic factors and risk for non-cancer mortality have not been evaluated.
We examined associations of active and passive smoke exposure with mortality among Hispanic (n=1,020) and non-Hispanic White (n=1,198) women with invasive breast cancer in the Breast Cancer Health Disparities Study (median follow-up of 10.6 years).
Risk of breast cancer-specific (HR=1.55, 95% CI:1.11-2.16) and all-cause (HR=1.68, 95% CI:1.30-2.17) mortality was increased for current smokers, with similar results stratified by ethnicity. Ever smokers had an increased risk of non-cancer mortality (HR=1.68, 95% CI:1.12-2.51). Associations were strongest for current smokers who smoked ≥20 years, were postmenopausal, overweight/obese, or reported moderate/high alcohol consumption; however, interactions were not significant. Breast cancer-specific mortality was increased 2-fold for moderate/high recent passive smoke exposure among never smokers (HR=2.12, 95% CI:1.24-3.63).
Findings support associations of active and passive smoking diagnosis with risk of breast cancer-specific and all-cause mortality, and ever smoking with non-cancer mortality, regardless of ethnicity and other factors. Smoking is a modifiable lifestyle factor and effective smoking cessation and maintenance programs should be routinely recommended for women with breast cancer.
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