Active and Passive Cigarette Smoking and Mortality among Hispanic and non-Hispanic White Women Diagnosed with Invasive Breast Cancer

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Boone, Stephanie D. ; Baumgartner, Kathy B. ; Baumgartner, Richard N. ; Connor, Avonne E. ; John, Esther M. ; Giuliano, Anna R. ; Hines, Lisa M. ; Rai, Shesh N. ; Riley, Elizabeth C. ; Pinkston, Christina M. ; Wolff, Roger K. ; Slattery, Martha L.
• Description:
  Purpose
  
  Women who smoke at breast cancer diagnosis have higher risk of breast cancer-specific and all-cause mortality than non-smokers; however, differences by ethnicity or prognostic factors and risk for non-cancer mortality have not been evaluated.
  
  Methods
  
  We examined associations of active and passive smoke exposure with mortality among Hispanic (n=1,020) and non-Hispanic White (n=1,198) women with invasive breast cancer in the Breast Cancer Health Disparities Study (median follow-up of 10.6 years).
  
  Results
  
  Risk of breast cancer-specific (HR=1.55, 95% CI:1.11-2.16) and all-cause (HR=1.68, 95% CI:1.30-2.17) mortality was increased for current smokers, with similar results stratified by ethnicity. Ever smokers had an increased risk of non-cancer mortality (HR=1.68, 95% CI:1.12-2.51). Associations were strongest for current smokers who smoked ≥20 years, were postmenopausal, overweight/obese, or reported moderate/high alcohol consumption; however, interactions were not significant. Breast cancer-specific mortality was increased 2-fold for moderate/high recent passive smoke exposure among never smokers (HR=2.12, 95% CI:1.24-3.63).
  
  Conclusions
  
  Findings support associations of active and passive smoking diagnosis with risk of breast cancer-specific and all-cause mortality, and ever smoking with non-cancer mortality, regardless of ethnicity and other factors. Smoking is a modifiable lifestyle factor and effective smoking cessation and maintenance programs should be routinely recommended for women with breast cancer.
  
  
• Keywords:
  Adult Aged Alcohol Drinking Body Mass Index Breast Cancer Breast Neoplasms Case-Control Studies Cause Of Death Ethnicity Female Hispanic Hispanic Or Latino Humans Incidence Middle Aged Mortality Native American Ancestry Population Surveillance Risk Factors Smoking Smoking Cessation Surveys And Questionnaires Survival Tobacco Smoke Pollution United States White People

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• Source:
  Ann Epidemiol. 25(11):824-831
• Pubmed ID:
  26387598
• Pubmed Central ID:
  PMC4609618
• Document Type:
  Journal Article
• Funding:
  CA77305/CA/NCI NIH HHSUnited States/ ; HHSN261201000036C/PHS HHSUnited States/ ; CA078682/CA/NCI NIH HHSUnited States/ ; R01 CA078552/CA/NCI NIH HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; R01 CA078762/CA/NCI NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA078802/CA/NCI NIH HHSUnited States/ ; R01 CA078682/CA/NCI NIH HHSUnited States/ ; 1U58 DP000807-01/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA140002/CA/NCI NIH HHSUnited States/ ; R01 CA063446/CA/NCI NIH HHSUnited States/ ; CA078552/CA/NCI NIH HHSUnited States/ ; N01-PC-67000/PC/NCI NIH HHSUnited States/ ; CA14002/CA/NCI NIH HHSUnited States/ ; CA078762/CA/NCI NIH HHSUnited States/ ; CA63446/CA/NCI NIH HHSUnited States/ ; CA078802/CA/NCI NIH HHSUnited States/
• Volume:
  25
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0ee9579891c15a833b4b3d8e5f9d0faf2354131becf8756b2969d4dd7afc5c4e
• Download URL:
  https://stacks.cdc.gov/view/cdc/37416/cdc_37416_DS1.pdf
• File Type:
  [PDF - 573.50 KB ]