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Zika CDC interim response plan : August 2016
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  • Description:
    Interim CDC Zika Response Plan (CONUS and Hawaii) Overview: Initial Response to Zika Virus Infections -- Stage -- Phase Level -- Transmission Risk Category -- Appendix A: Local Transmission of Zika Virus -- Appendix B: CDC’s Emergency Response Team (CERT) -- Appendix C: Communication -- Stage -- Phase Level -- Transmission Risk Category -- Appendix D. Surveillance -- Appendix E. Vector Control -- Stage -- Phase Level -- Transmission Risk Category -- Appendix F: Pregnancy and Birth Defects -- Appendix G: Ensuring Blood Safety and Availability.

    The purpose of this document is to describe the Centers for Disease Control and Prevention (CDC) response plan for locally acquired cases of Zika virus infection in the continental United States and Hawaii. Zika virus is spread to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. The response activities outlined in this plan are based on currently available knowledge about Zika virus and its transmission, and these activities may change as more is learned about Zika virus infection. Most of the plan focuses on response activities that would occur after locally acquired Zika virus transmission has been identified. CDC also is committed to responding to travel- associated and sexually transmitted Zika virus infections reported in the United States (US) before detection of locally transmitted cases of Zika virus infection.

    This version of the CDC Interim Zika Response Plan replaces the previous document posted on June 14, 2016. Notable updates include:

    • Revised guidance is included on the risk of Zika virus transmission, including the potential for sexual transmission both from men and women to sex partners.

    • When a case of locally acquired Zika virus infection is identified, state and local health departments should initiate interventions and target these interventions appropriately. Based on available epidemiologic, entomologic, and environmental information, states will define geographic areas for targeted Zika virus interventions.

    • The described continuum of preparedness to response has been condensed from 5 phases (0 to 4) to 4 phases (0 to 3). Transmission phases have been reorganized and renamed: “Suspect case of local transmission,” “Confirmed local transmission,” and “Confirmed multiperson local transmission.”

    • Guidance on the determination of geographic areas for interventions and issuance of travel guidance in the setting of local transmission has been revised.

    • Revised Zika virus laboratory testing guidance: RT-PCR testing of serum and urine is recommended less than 14 days after symptom onset. An approved serologic assay should be used for testing of serum collected 14 days to 12 weeks after symptom onset and for RT-PCR negative serum collected within 14 days of illness onset.

    • Enhanced case identification is described to include outreach to physicians to encourage Zika virus testing among pregnant women and among patients with clinically compatible illness in areas where Aedes aegypti and Aedes albopictus mosquitoes are likely to be abundant and where travel-associated cases have been identified.

    • Birth defects among infants born to women with Zika infection during pregnancy should be reported to state-based birth defects surveillance systems. CDC will work with jurisdictions to establish or enhance population-based surveillance systems for microcephaly and other Zika-related adverse fetal and infant outcomes.

    Suggested Citation: Centers for Disease Control and Prevention. Interim CDC Zika Response Plan (CONUS and Hawaii): Initial Response to Zika Virus. Atlanta, Georgia: August 2016.


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