Use of Testing for West Nile Virus and Other Arboviruses

Vanichanan, Jakapat; Salazar, Lucrecia; Wootton, Susan H.; Aguilera, Elizabeth; Garcia, Melissa N.; Murray, Kristy O.; Hasbun, Rodrigo

doi:10.3201/eid2209.152050

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Use of Testing for West Nile Virus and Other Arboviruses

Published Date:

Sep 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2209.152050 New Site Icon

Source:

Emerg Infect Dis. 22(9):1587-1593.

[PDF-510.45 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Vanichanan, Jakapat ; Salazar, Lucrecia ; Wootton, Susan H. ; Aguilera, Elizabeth ; Garcia, Melissa N. ; ... More ▼

Description:

In the United States, the most commonly diagnosed arboviral disease is West Nile virus (WNV) infection. Diagnosis is made by detecting WNV IgG or viral genomic sequences in serum or cerebrospinal fluid. To determine frequency of this testing in WNV-endemic areas, we examined the proportion of tests ordered for patients with meningitis and encephalitis at 9 hospitals in Houston, Texas, USA. We identified 751 patients (567 adults, 184 children), among whom 390 (52%) experienced illness onset during WNV season (June-October). WNV testing was ordered for 281 (37%) of the 751; results indicated acute infection for 32 (11%). Characteristics associated with WNV testing were acute focal neurologic deficits; older age; magnetic resonance imaging; empirically prescribed antiviral therapy; worse clinical outcomes: and concomitant testing for mycobacterial, fungal, or other viral infections. Testing for WNV is underutilized, and testing of patients with more severe disease raises the possibility of diagnostic bias in epidemiologic studies.

Subject:

[+]

Pubmed ID:

27537988

Pubmed Central ID:

PMC4994361

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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Supporting Files:

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