Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014

Aliabadi, Negar; Messacar, Kevin; Pastula, Daniel M.; Robinson, Christine C.; Leshem, Eyal; Sejvar, James J.; Nix, W. Allan; Oberste, M. Steven; Feikin, Daniel R.; Dominguez, Samuel R.

doi:10.3201/eid2208.151949

i

Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014

Supporting Files Public Domain

Aug 2016
By Aliabadi, Negar ; Messacar, Kevin ; Pastula, Daniel M. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Aliabadi, Negar ; Messacar, Kevin ; Pastula, Daniel M. ; Robinson, Christine C. ; Leshem, Eyal ; Sejvar, James J. ; Nix, W. Allan ; Oberste, M. Steven ; Feikin, Daniel R. ; Dominguez, Samuel R.
Description:

During August 8, 2014-October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. To determine whether an association exists between EV-D68 infection and acute flaccid myelitis, we conducted a retrospective case-control study comparing these patients with 2 groups of outpatient control children (1 group tested for acute respiratory illness and 1 for Bordetella pertussis infection). Adjusted analyses indicated that, for children with acute flaccid myelitis, the odds of having EV-D68 infection were 10.3 times greater than for those tested for acute respiratory infection and 4.5 times greater than for those tested for B. pertussis infection. No statistical association was seen between acute flaccid myelitis and non-EV-D68 enterovirus or rhinovirus infection. These findings support an association between EV-D68 infection and acute flaccid myelitis.
Subjects:

Adolescent Case-Control Studies Child Child, Preschool Disease Outbreaks Enterovirus D, Human/isolation & Purification Enterovirus Infections/epidemiology Enterovirus Infections/virology Female Humans Infant Male Myelitis/epidemiology Myelitis/virology Research Retrospective Studies Time Factors
Source:

Emerg Infect Dis. 22(8):1387-1394.
Pubmed ID:

27434186
Pubmed Central ID:

PMC4982171
Document Type:

Journal Article
Place as Subject:

Colorado
Location:

North America
Volume:

22
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:06f3c802d0c0e452d1f17f2fab2549ae7a095008763414ff04acfefac51ab82d
Download URL:

https://stacks.cdc.gov/view/cdc/40857/cdc_40857_DS1.pdf
File Type:

[PDF - 971.95 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.