Outbreak of Type 1 Wild Poliovirus Infection in Adults, Namibia, 2006

Yusuf, Nasir; de Wee, Rosalina; Foster, Norbert; Watkins, Margaret A.; Tiruneh, Desta; Chauvin, Claire; Bossarte, Robert; Mandlhate, Custodia; Jack, Abdoulie; Gumede, Nicksy; Mawela, Alfred; Burns, Cara C.; Pallansch, Mark A.; Allies, Tina; Rainey, Jeannette; Mataruse, Noah; Nshimirimana, Deo

doi:10.1093/infdis/jiu069

i

Outbreak of Type 1 Wild Poliovirus Infection in Adults, Namibia, 2006

Supporting Files

11 01 2014
By Yusuf, Nasir ; de Wee, Rosalina ; Foster, Norbert ; ...

File Language:

English

Details

Alternative Title:

J Infect Dis
Personal Author:

Yusuf, Nasir ; de Wee, Rosalina ; Foster, Norbert ; Watkins, Margaret A. ; Tiruneh, Desta ; Chauvin, Claire ; Bossarte, Robert ; Mandlhate, Custodia ; Jack, Abdoulie ; Gumede, Nicksy ; Mawela, Alfred ; Burns, Cara C. ; Pallansch, Mark A. ; Allies, Tina ; Rainey, Jeannette ; Mataruse, Noah ; Nshimirimana, Deo
Description:

A paralytic poliomyelitis outbreak occurred in Namibia in 2006, almost exclusively among adults. Nineteen cases were virologically confirmed as due to wild poliovirus type 1 (WPV1), and 26 were classified as polio compatible. Eleven deaths occurred among confirmed and compatible cases (24%). Of the confirmed cases, 97% were aged 15-45 years, 89% were male, and 71% lived in settlement areas in Windhoek. The virus was genetically related to a virus detected in 2005 in Angola, which had been imported earlier from India. The outbreak is likely due to immunity gaps among adults who were inadequately vaccinated during childhood. This outbreak underscores the ongoing risks posed by poliovirus importations, the importance of maintaining strong acute flaccid paralysis surveillance even in adults, and the need to maintain high population immunity to avoid polio outbreaks in the preeradication period and outbreaks due to vaccine-derived polioviruses in the posteradication era.
Keywords:

Adolescent Adult Age Factors Case-Control Studies Child Child, Preschool Disease Outbreak Disease Outbreaks Female Humans Infant Infant, Newborn Male Middle Aged Namibia Paralysis Poliomyelitis Poliovirus Sex Distribution Topography, Medical Type 1 Wild Poliovirus Young Adult
Source:

J Infect Dis. 210(Suppl 1):S353-S360
Pubmed ID:

25316855
Pubmed Central ID:

PMC10544111
Document Type:

Journal Article
Funding:

001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

210
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:d326a9df72f0e62769fbc9c46c88deb8bcfa924975a14a7ba852d9c88de5a502
Download URL:

https://stacks.cdc.gov/view/cdc/133840/cdc_133840_DS1.pdf
File Type:

[PDF - 1.43 MB ]

File Language:

English

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