Cooperative subnetworks of molecularly-similar interneurons in mouse neocortex

Details

• Alternative Title:
  Neuron
• Personal Author:
  Karnani, Mahesh M ; Jackson, Jesse ; Ayzenshtat, Inbal ; Tucciarone, Jason ; Manoocheri, Kasra ; Snider, William G ; Yuste, Rafael
• Description:
  Simultaneous co-activation of neocortical neurons is likely critical for brain computations ranging from perception and motor control to memory and cognition. While co-activation of excitatory principal cells (PCs) during ongoing activity has been extensively studied, that of inhibitory interneurons (INs) has received little attention. Here, we show in vivo and in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM) or vasoactive intestinal peptide (VIP), are active as populations rather than individually. We demonstrate a variety of synergistic mechanisms, involving population-specific local excitation, GABAergic disinhibition and excitation through electrical coupling, which likely underlie IN population co-activity. Firing of a few SOM or VIP INs recruits additional members within the cell type via GABAergic and cholinergic mechanisms, thereby amplifying the output of the population as a whole. Our data suggest that IN populations work as cooperative units, thus generating an amplifying nonlinearity in their circuit output.
• Keywords:
  • Acetylcholine
  • Animals
  • In Vitro Techniques
  • Interneurons
  • Mice
  • Neocortex
  • Neural Inhibition
  • Neurons
  • Patch-Clamp Techniques
  • Pyramidal Cells
  More +
• Source:
  Neuron. 90(1):86-100
• Pubmed ID:
  27021171
• Pubmed Central ID:
  PMC4961215
• Document Type:
  Journal Article
• Funding:
  R01MH101218/MH/NIMH NIH HHSUnited States/ ; R01 MH100561/MH/NIMH NIH HHSUnited States/ ; R01 MH101218/MH/NIMH NIH HHSUnited States/ ; DP1 EY024503/EY/NEI NIH HHSUnited States/ ; R01 EY011787/EY/NEI NIH HHSUnited States/ ; DP1EY024503/DP/NCCDPHP CDC HHSUnited States/ ; R01EY011787/EY/NEI NIH HHSUnited States/
• Volume:
  90
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/40734/cdc_40734_DS1.pdf
• File Type:
  [PDF - 2.24 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f058f7a05e549b404eeede0c6ed2c54749b5e6feaf1c480bc8ae09f7c681510d