Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition

Lee, Anthony T.; Gee, Steven M.; Vogt, Daniel; Rubenstein, John L.; Sohal, Vikaas S.

doi:10.1016/j.neuron.2013.10.031

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Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition

Published Date:

Dec 19 2013

Publisher's site:

http://dx.doi.org/10.1016/j.neuron.2013.10.031 New Site Icon

Source:

Neuron. 2013; 81(1):61-68.

[PDF - 1.70 MB]

Details:

Personal Authors:

Lee, Anthony T. ; Gee, Steven M. ; Vogt, Daniel ; Rubenstein, John L. ; Sohal, Vikaas S. ;

Keywords:

[+]

Pubmed ID:

24361076

Pubmed Central ID:

PMC3947199

Description:

Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted, callosally projecting type B neurons, which lack prominent h-current. Using optogenetic stimulation, we find that these subtypes receive distinct forms of input that could subserve divergent functions. Repeatedly stimulating callosal inputs evokes progressively smaller excitatory responses in type B but not type A neurons. Callosal inputs also elicit more spikes in type A neurons. Surprisingly, these effects arise via distinct mechanisms. Differences in the dynamics of excitatory responses seem to reflect differences in presynaptic input, whereas differences in spiking depend on postsynaptic mechanisms. We also find that fast-spiking parvalbumin interneurons, but not somatostatin interneurons, preferentially inhibit type A neurons, leading to greater feedforward inhibition in this subtype. These differences may enable type A neurons to detect salient inputs that are focused in space and time, while type B neurons integrate across these dimensions.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 MH100011/MH/NIMH NIH HHS/United States
DP2MH100011/DP/NCCDPHP CDC HHS/United States
GM07618/GM/NIGMS NIH HHS/United States
R00 MH085946/MH/NIMH NIH HHS/United States
R00MH085946/MH/NIMH NIH HHS/United States
R37 MH049428/MH/NIMH NIH HHS/United States
R37MH049428/MH/NIMH NIH HHS/United States
T32 GM007618/GM/NIGMS NIH HHS/United States

Supporting Files:

NIHMS532262-supplement-01.pdf	application/pdf
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