Details:

Alternative Title:
Neuron
Publisher's site:
http://dx.doi.org/10.1016/j.neuron.2013.10.031
Personal Author:
Lee, Anthony T. ; Gee, Steven M. ; Vogt, Daniel ; Rubenstein, John L. ; Sohal, Vikaas S. ;
Lee, Anthony T. ; Gee, Steven M. ; Vogt, Daniel ; Rubenstein, John L. ; Sohal, Vikaas S. ; Less -
Description:
Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted, callosally projecting type B neurons, which lack prominent h-current. Using optogenetic stimulation, we find that these subtypes receive distinct forms of input that could subserve divergent functions. Repeatedly stimulating callosal inputs evokes progressively smaller excitatory responses in type B but not type A neurons. Callosal inputs also elicit more spikes in type A neurons. Surprisingly, these effects arise via distinct mechanisms. Differences in the dynamics of excitatory responses seem to reflect differences in presynaptic input, whereas differences in spiking depend on postsynaptic mechanisms. We also find that fast-spiking parvalbumin interneurons, but not somatostatin interneurons, preferentially inhibit type A neurons, leading to greater feedforward inhibition in this subtype. These differences may enable type A neurons to detect salient inputs that are focused in space and time, while type B neurons integrate across these dimensions.
Subject:
[+]
Action Potentials
Animals
Article
Calcium
Dependovirus
Electric Stimulation
Excitatory Postsynaptic Potentials
Female
Green Fluorescent Proteins
In Vitro Techniques
Male
Mice
Nerve Net
Neural Inhibition
Neural Pathways
Neurotransmitter Agents
Patch-Clamp Techniques
Prefrontal Cortex
Pyramidal Cells
Rhodopsin
Synapses
Transduction, Genetic

Source:
Neuron. 2013 ; 81(1):61-68.;
Pubmed ID:
24361076
Pubmed Central ID:
PMC3947199
Document Type:
Journal Article ;
Funding:
DP2 MH100011/MH/NIMH NIH HHS/United States ; DP2MH100011/DP/NCCDPHP CDC HHS/United States ; GM07618/GM/NIGMS NIH HHS/United States ; R00 MH085946/MH/NIMH NIH HHS/United States ; R00MH085946/MH/NIMH NIH HHS/United States ; ... More +
DP2 MH100011/MH/NIMH NIH HHS/United States ; DP2MH100011/DP/NCCDPHP CDC HHS/United States ; GM07618/GM/NIGMS NIH HHS/United States ; R00 MH085946/MH/NIMH NIH HHS/United States ; R00MH085946/MH/NIMH NIH HHS/United States ; R37 MH049428/MH/NIMH NIH HHS/United States ; R37MH049428/MH/NIMH NIH HHS/United States ; T32 GM007618/GM/NIGMS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5451156619503caf8a78dea7c52a25616d70de8e6cdfeb8aaede07dc1d8f02f7
File Type:

Supporting Files

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