i
Superseded
This Document Has Been Replaced By:
i
Retired
This Document Has Been Retired
i
Up-to-date Information
This is the latest update:
Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition
-
Published Date:
Dec 19 2013
-
Publisher's site:
-
Source:Neuron. 2013; 81(1):61-68.
-
Details:
-
Alternative Title:Neuron
-
Personal Author:
-
Description:Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted, callosally projecting type B neurons, which lack prominent h-current. Using optogenetic stimulation, we find that these subtypes receive distinct forms of input that could subserve divergent functions. Repeatedly stimulating callosal inputs evokes progressively smaller excitatory responses in type B but not type A neurons. Callosal inputs also elicit more spikes in type A neurons. Surprisingly, these effects arise via distinct mechanisms. Differences in the dynamics of excitatory responses seem to reflect differences in presynaptic input, whereas differences in spiking depend on postsynaptic mechanisms. We also find that fast-spiking parvalbumin interneurons, but not somatostatin interneurons, preferentially inhibit type A neurons, leading to greater feedforward inhibition in this subtype. These differences may enable type A neurons to detect salient inputs that are focused in space and time, while type B neurons integrate across these dimensions.
-
Subject:
-
Pubmed ID:24361076
-
Pubmed Central ID:PMC3947199
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
image/gif image/jpeg application/pdf application/octet-stream image/gif image/jpeg image/gif image/jpeg image/gif image/jpeg
No Related Documents.