Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition

Lee, Anthony T.; Gee, Steven M.; Vogt, Daniel; Rubenstein, John L.; Sohal, Vikaas S.

doi:10.1016/j.neuron.2013.10.031

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition

Published Date:

Dec 19 2013

Publisher's site:

http://dx.doi.org/10.1016/j.neuron.2013.10.031 New Site Icon

Source:

Neuron. 2013; 81(1):61-68.

[PDF - 1.70 MB]

Details:

Personal Authors:

Lee, Anthony T. ; Gee, Steven M. ; Vogt, Daniel ; Rubenstein, John L. ; Sohal, Vikaas S. ;

Keywords:

[+]

Pubmed ID:

24361076

Pubmed Central ID:

PMC3947199

Description:

Layer 5 pyramidal neurons comprise at least two subtypes: thick-tufted, subcortically projecting type A neurons, with prominent h-current, and thin-tufted, callosally projecting type B neurons, which lack prominent h-current. Using optogenetic stimulation, we find that these subtypes receive distinct forms of input that could subserve divergent functions. Repeatedly stimulating callosal inputs evokes progressively smaller excitatory responses in type B but not type A neurons. Callosal inputs also elicit more spikes in type A neurons. Surprisingly, these effects arise via distinct mechanisms. Differences in the dynamics of excitatory responses seem to reflect differences in presynaptic input, whereas differences in spiking depend on postsynaptic mechanisms. We also find that fast-spiking parvalbumin interneurons, but not somatostatin interneurons, preferentially inhibit type A neurons, leading to greater feedforward inhibition in this subtype. These differences may enable type A neurons to detect salient inputs that are focused in space and time, while type B neurons integrate across these dimensions.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 MH100011/MH/NIMH NIH HHS/United States
DP2MH100011/DP/NCCDPHP CDC HHS/United States
GM07618/GM/NIGMS NIH HHS/United States
R00 MH085946/MH/NIMH NIH HHS/United States
R00MH085946/MH/NIMH NIH HHS/United States
R37 MH049428/MH/NIMH NIH HHS/United States
R37MH049428/MH/NIMH NIH HHS/United States
T32 GM007618/GM/NIGMS NIH HHS/United States

Supporting Files:

NIHMS532262-supplement-01.pdf	application/pdf
nihms532262.nxml	application/octet-stream
nihms532262f1.gif	image/gif
nihms532262f1.jpg	image/jpeg
nihms532262f2.gif	image/gif
nihms532262f2.jpg	image/jpeg
nihms532262f3.gif	image/gif
nihms532262f3.jpg	image/jpeg
nihms532262f4.gif	image/gif
nihms532262f4.jpg	image/jpeg

No Related Documents.

You May Also Like:

Membrane Potential Dynamics of CA1 Pyramidal Neurons During Hippocampal Ripples in Awake Mice

Personal Author:

Hulse, Brad K.; Moreaux, Laurent C.; Lubenov, Evgueniy V.; Siapas, Athanassios G.;

Published:

Feb 17 2016

Source:

Neuron. 89(4):800-813.

Description:

Ripples are high-frequency oscillations associated with population bursts in area CA1 of the hippocampus that play a prominent role in theories of memory consolidation. While spiking during ripples has been extensively studied, our understanding of t...

File Type:

[PDF - 2.75 MB]
Costs and benefits of a subtype-specific surveillance system for identifying Escherichia coli O157:H7 outbreaks.

Personal Author:

Elbasha, E. H.; Fitzsimmons, T. D.; Meltzer, M. I.;

Published:

2000 May-Jun

Source:

Emerg Infect Dis. 6(3):293-297.

Description:

We assessed the societal costs and benefits of a subtype-specific surveillance system for identifying outbreak-associated Escherichia coli O157:H7 infections. Using data from Colorado, we estimated that if it averted five cases annually, the system w...

File Type:

[PDF - 42.48 KB]
Studies of Hot Photoluminescence in Plasmonically Coupled Silicon via Variable Energy Excitation and Temperature-Dependent Spectroscopy

Personal Author:

Aspetti, Carlos O.; Cho, Chang-Hee; Agarwal, Rahul; Agarwal, Ritesh;

Published:

Aug 18 2014

Source:

Nano Lett. 2014; 14(9):5413-5422.

Description:

By integrating silicon nanowires (∼150 nm diameter, 20 μm length) with an Ω-shaped plasmonic nanocavity, we are able to generate broadband visible luminescence, which is induced by high order hybrid nanocavity-surface plasmon modes. The nature of...

File Type:

[PDF - 3.39 MB]
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex

Personal Author:

Kaufman, Matthew T; Churchland, Mark M; Ryu, Stephen I; Shenoy, Krishna V;

Published:

May 05 2015

Source:

eLife. 2015; 4.

Description:

When choosing actions, we can act decisively, vacillate, or suffer momentary indecision. Studying how individual decisions unfold requires moment-by-moment readouts of brain state. Here we provide such a view from dorsal premotor and primary motor co...

File Type:

[PDF - 3.53 MB]
Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain

Personal Author:

Sayeg, Marianna K.; Weinberg, Benjamin H.; Cha, Susie S.; Goodloe, Michael; Wong, Wilson W.; Han, Xue;

Published:

Apr 13 2015

Source:

ACS Synth Biol. 4(7):788-795.

Description:

Targeting transgene expression to specific cell types in vivo has proven instrumental in characterizing the functional role of defined cell populations. Genetic classifiers, synthetic transgene constructs designed to restrict expression to particular...

File Type:

[PDF - 968.88 KB]