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Determining the familial risk distribution of colorectal cancer: A data mining approach
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Details:
  • Pubmed ID:
    26681340
  • Pubmed Central ID:
    PMC4803603
  • Description:
    This study was aimed to characterize the distribution of colorectal cancer risk using family history of cancers by data mining. Family histories for 10,066 colorectal cancer cases recruited to population cancer registries of the Colon Cancer Family Registry were analyzed using a data mining framework. A novel index was developed to quantify familial cancer aggregation. Artificial neural network was used to identify distinct categories of familial risk. Standardized incidence ratios (SIRs) and corresponding 95% confidence intervals (CIs) of colorectal cancer were calculated for each category. We identified five major, and 66 minor categories of familial risk for developing colorectal cancer. The distribution the major risk categories were: (1) 7% of families (SIR = 7.11; 95% CI 6.65-7.59) had a strong family history of colorectal cancer; (2) 13% of families (SIR = 2.94; 95% CI 2.78-3.10) had a moderate family history of colorectal cancer; (3) 11% of families (SIR = 1.23; 95% CI 1.12-1.36) had a strong family history of breast cancer and a weak family history of colorectal cancer; (4) 9 % of families (SIR = 1.06; 95 % CI 0.96-1.18) had strong family history of prostate cancer and weak family history of colorectal cancer; and (5) 60% of families (SIR = 0.61; 95% CI 0.57-0.65) had a weak family history of all cancers. There is a wide variation of colorectal cancer risk that can be categorized by family history of cancer, with a strong gradient of colorectal cancer risk between the highest and lowest risk categories. The risk of colorectal cancer for people with the highest risk category of family history (7% of the population) was 12-times that for people in the lowest risk category (60%) of the population. Data mining was proven an effective approach for gaining insight into the underlying cancer aggregation patterns and for categorizing familial risk of colorectal cancer.

  • Document Type:
  • Collection(s):
  • Funding:
    HHSN261201000034C/PHS HHS/United States
    N01-PC-35142/PC/NCI NIH HHS/United States
    U58DP003862-01/DP/NCCDPHP CDC HHS/United States
    HHSN261201000035C/PC,CA/None/None
    U01 CA074799/CA/NCI NIH HHS/United States
    U01/U24 CA074799/CA/NCI NIH HHS/United States
    U24 CA074783/CA/NCI NIH HHS/United States
    N01 CN067009/CN/NCI NIH HHS/United States
    HHSN261201000035C/PHS HHS/United States
    U24 CA074794/CA/NCI NIH HHS/United States
    HHSN2612013000121/PHS HHS/United States
    U24 CA074806/CA/NCI NIH HHS/United States
    U24 CA097735/CA/NCI NIH HHS/United States
    U01 CA074794/CA/NCI NIH HHS/United States
    HHSN261201300012I/CA/NCI NIH HHS/United States
    N01PC35142/CA/NCI NIH HHS/United States
    HHSN261201000035I/CA/NCI NIH HHS/United States
    U01/U24 CA074783/CA/NCI NIH HHS/United States
    U01/U24 CA074794/CA/NCI NIH HHS/United States
    HHSN261201000034C/CA/NCI NIH HHS/United States
    U01 CA097735/CA/NCI NIH HHS/United States
    UM1 CA167551/CA/NCI NIH HHS/United States
    U58 DP003862/DP/NCCDPHP CDC HHS/United States
    U01 CA074783/CA/NCI NIH HHS/United States
    U01/U24 CA097735/CA/NCI NIH HHS/United States
    U24 CA074799/CA/NCI NIH HHS/United States
    U01 CA074806/CA/NCI NIH HHS/United States
    U24 CA074800/CA/NCI NIH HHS/United States
    HHSN261201000121C/CP/NCI NIH HHS/United States
    U01 CA074800/CA/NCI NIH HHS/United States
    U01/U24 CA074800/CA/NCI NIH HHS/United States
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