Details:

Alternative Title:
Org Lett
Publisher's site:
http://dx.doi.org/10.1021/acs.orglett.6b00380
Personal Author:
Sato, Michio ; Winter, Jaclyn M. ; Noguchi, Hiroshi ; Tang, Yi ; Watanabe, Kenji
Sato, Michio ; Winter, Jaclyn M. ; Noguchi, Hiroshi ; Tang, Yi ; Watanabe, Kenji Less -
Description:
Chaetoviridins constitute a large family of structurally related secondary metabolites isolated from Chaetomium fungi. To elucidate the biosynthesis pathway and understand how the chemical diversity of chaetoviridins is generated, gene deletion and in vitro characterization of the four post-PKS modifications enzymes were undertaken. CazL and CazP were identified to have substrate promiscuity that facilitates the formation of nonchlorinated analogues. In addition, enzymatic oxidation and reduction combined with spontaneous dehydration and lactonization of the intermediates further expand the chemical diversity.
Subject:
[+]
Article
Biosynthetic Pathways
Chaetomium
Furans
Gene Deletion
Molecular Structure
Oxidation-Reduction
Polyketide Synthases
Pyrones

Source:
Org Lett. 18(6):1446-1449.
Pubmed ID:
26959241
Pubmed Central ID:
PMC4903021
Document Type:
Journal Article
Funding:
DP1 GM106413/GM/NIGMS NIH HHS/United States ; R01 GM085128/GM/NIGMS NIH HHS/United States ; 1DP1GM106413/DP/NCCDPHP CDC HHS/United States
DP1 GM106413/GM/NIGMS NIH HHS/United States ; R01 GM085128/GM/NIGMS NIH HHS/United States ; 1DP1GM106413/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:134d7761a71e5da5968d4f1033b2957ec612ba73ecdac2e00101e5b8781bccce
File Type:

Supporting Files

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