Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study
Published Date:Feb 22 2016
Source:Cancer Causes Control. 27(4):527-543.
Pubmed Central ID:PMC4821634
Funding:K01 CA160607/CA/NCI NIH HHS/United States
P30 ES007048/ES/NIEHS NIH HHS/United States
CA77305/CA/NCI NIH HHS/United States
N01 CN067000-003/CN/NCI NIH HHS/United States
HHSN261201000036C/PHS HHS/United States
CA078682/CA/NCI NIH HHS/United States
R01 CA078552/CA/NCI NIH HHS/United States
HHSN261201000036C/CA/NCI NIH HHS/United States
P30CA014089/CA/NCI NIH HHS/United States
R01 CA078762/CA/NCI NIH HHS/United States
U58 DP000807/DP/NCCDPHP CDC HHS/United States
R01 CA078802/CA/NCI NIH HHS/United States
R01 CA078682/CA/NCI NIH HHS/United States
P30 CA014089/CA/NCI NIH HHS/United States
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States
R01 CA140002/CA/NCI NIH HHS/United States
5T32 ES013678/ES/NIEHS NIH HHS/United States
N01 CN067000/CN/NCI NIH HHS/United States
R01 CA063446/CA/NCI NIH HHS/United States
T32 ES013678/ES/NIEHS NIH HHS/United States
CA078552/CA/NCI NIH HHS/United States
N01-PC-67000/PC/NCI NIH HHS/United States
CA14002/CA/NCI NIH HHS/United States
CA078762/CA/NCI NIH HHS/United States
5P30 ES07048/ES/NIEHS NIH HHS/United States
CA078802/CA/NCI NIH HHS/United States
There is suggestive but limited evidence for a relationship between meat intake and breast cancer (BC) risk. Few studies included Hispanic women. We investigated the association between meats and fish intake and BC risk among Hispanic and NHW women.
The study included NHW (1,982 cases and 2,218 controls) and US Hispanics (1,777 cases and 2,218 controls) from 2 population-based case-control studies. Analyses considered menopausal status and percent Native American ancestry. We estimated pooled ORs combining harmonized data from both studies, and study and race/ethnicity specific ORs that were combined using fixed or random effects models, depending on heterogeneity levels.
When comparing highest versus lowest tertile of intake, among NHW we observed an association between tuna intake and BC risk (pooled OR = 1.25; 95% CI = 1.05–1.50; trend p = 0.006),. Among Hispanics, we observed an association between BC risk and processed meat intake (pooled OR = 1.42; 95% CI 1.18–1.71; trend p < 0.001), and between white meat (OR = 0.80; 95% CI 0.67–0.95; trend p = 0.01) and BC risk, driven by poultry. All these findings were supported by meta-analysis using fixed or random effect models, and were restricted to estrogen receptor positive tumors. Processed meats and poultry were not associated with BC risk among NHW women; red meat and fish were not associated with BC risk in either race/ethnic groups.
Our results suggest the presence of ethnic differences in associations between meat and BC risk that may contribute to BC disparities.
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