Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2207.160116
Personal Author:
Simmons, Graham ; Brès, Vanessa ; Lu, Kai ; Liss, Nathan M. ; Brambilla, Donald J. ; ... More +
Simmons, Graham ; Brès, Vanessa ; Lu, Kai ; Liss, Nathan M. ; Brambilla, Donald J. ; Ryff, Kyle R. ; Bruhn, Roberta ; Velez, Edwin ; Ocampo, Derrek ; Linnen, Jeffrey M. ; Latoni, Gerardo ; Petersen, Lyle R. ; Williamson, Phillip C. ; Busch, Michael P. Less -
Description:
Chikungunya virus (CHIKV) caused large epidemics throughout the Caribbean in 2014. We conducted nucleic acid amplification testing (NAAT) for CHIKV RNA (n = 29,695) and serologic testing for IgG against CHIKV (n = 1,232) in archived blood donor samples collected during and after an epidemic in Puerto Rico in 2014. NAAT yields peaked in October with 2.1% of donations positive for CHIKV RNA. A total of 14% of NAAT-reactive donations posed a high risk for virus transmission by transfusion because of high virus RNA copy numbers (10 (4) -10 (9) RNA copies/mL) and a lack of specific IgM and IgG responses. Testing of minipools of 16 donations would not have detected 62.5% of RNA-positive donations detectable by individual donor testing, including individual donations without IgM and IgG. Serosurveys before and after the epidemic demonstrated that nearly 25% of blood donors in Puerto Rico acquired CHIKV infections and seroconverted during the epidemic.
Subject:
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Blood Donors Chikungunya Fever Chikungunya Virus Epidemics Expedited Humans Incidence Nucleic Acid Amplification Techniques Serologic Tests Viremia
Source:
Emerg Infect Dis. 22(7):1221-1228.
Pubmed ID:
27070192
Pubmed Central ID:
PMC4918147
Document Type:
Journal Article
Place as Subject:
Puerto Rico
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8273b4d5eb303ac2b091e263c869080035b079decc666b08c67e6b891a91a574
Download URL:
https://stacks.cdc.gov/view/cdc/40201/cdc_40201_DS1.pdf
File Type:

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