High Incidence of Chikungunya Virus and Frequency of Viremic Blood Donations during Epidemic, Puerto Rico, USA, 2014

Simmons, Graham; Brès, Vanessa; Lu, Kai; Liss, Nathan M.; Brambilla, Donald J.; Ryff, Kyle R.; Bruhn, Roberta; Velez, Edwin; Ocampo, Derrek; Linnen, Jeffrey M.; Latoni, Gerardo; Petersen, Lyle R.; Williamson, Phillip C.; Busch, Michael P.

doi:10.3201/eid2207.160116

i

High Incidence of Chikungunya Virus and Frequency of Viremic Blood Donations during Epidemic, Puerto Rico, USA, 2014

Supporting Files Public Domain

Jul 15 2016
By Simmons, Graham ; Brès, Vanessa ; Lu, Kai ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Simmons, Graham ; Brès, Vanessa ; Lu, Kai ; Liss, Nathan M. ; Brambilla, Donald J. ; Ryff, Kyle R. ; Bruhn, Roberta ; Velez, Edwin ; Ocampo, Derrek ; Linnen, Jeffrey M. ; Latoni, Gerardo ; Petersen, Lyle R. ; Williamson, Phillip C. ; Busch, Michael P.
Description:

Chikungunya virus (CHIKV) caused large epidemics throughout the Caribbean in 2014. We conducted nucleic acid amplification testing (NAAT) for CHIKV RNA (n = 29,695) and serologic testing for IgG against CHIKV (n = 1,232) in archived blood donor samples collected during and after an epidemic in Puerto Rico in 2014. NAAT yields peaked in October with 2.1% of donations positive for CHIKV RNA. A total of 14% of NAAT-reactive donations posed a high risk for virus transmission by transfusion because of high virus RNA copy numbers (10 (4) -10 (9) RNA copies/mL) and a lack of specific IgM and IgG responses. Testing of minipools of 16 donations would not have detected 62.5% of RNA-positive donations detectable by individual donor testing, including individual donations without IgM and IgG. Serosurveys before and after the epidemic demonstrated that nearly 25% of blood donors in Puerto Rico acquired CHIKV infections and seroconverted during the epidemic.
Subjects:

Blood Donors Chikungunya Fever Chikungunya Virus Epidemics Expedited Humans Incidence Nucleic Acid Amplification Techniques Serologic Tests Viremia
Source:

Emerg Infect Dis. 22(7):1221-1228.
Pubmed ID:

27070192
Pubmed Central ID:

PMC4918147
Document Type:

Journal Article
Place as Subject:

Puerto Rico
Location:

Caribbean
Volume:

22
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:8273b4d5eb303ac2b091e263c869080035b079decc666b08c67e6b891a91a574
Download URL:

https://stacks.cdc.gov/view/cdc/40201/cdc_40201_DS1.pdf
File Type:

[PDF - 718.40 KB ]

File Language:

English

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