Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Crameri, Gary ; Durr, Peter A. ; Klein, Reuben ; Foord, Adam ; Yu, Meng ; Riddell, Sarah ; Haining, Jessica ; Johnson, Dayna ; Hemida, Maged G. ; Barr, Jennifer ; Peiris, Malik ; Middleton, Deborah ; Wang, Lin-Fa ; Crameri, Gary ; Durr, Peter A. ; Klein, Reuben ; Foord, Adam ; Yu, Meng ; Riddell, Sarah ; Haining, Jessica ; Johnson, Dayna ; Hemida, Maged G. ; Barr, Jennifer ; Peiris, Malik ; Middleton, Deborah ; Wang, Lin-Fa
• Description:
  We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.
• Subjects:
  Animals Antibodies, Neutralizing Antibodies, Viral Camelids, New World Coronavirus Infections Disease Models, Animal Female Middle East Respiratory Syndrome Coronavirus Neutralization Tests Viral Load Virus Shedding

  More +
• Source:
  Emerg Infect Dis. 22(6):1071-1074. ; Emerg Infect Dis. 22(6):1071-1074.
• Pubmed ID:
  27070733
• Pubmed Central ID:
  PMC4880109
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:eff6286e4c029792d2104acff5d57faab704cfb9d50f6e7bd835b0080cb298ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/39702/cdc_39702_DS1.pdf
• File Type:
  [PDF - 736.50 KB ]