Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus

Crameri, Gary; Durr, Peter A.; Klein, Reuben; Foord, Adam; Yu, Meng; Riddell, Sarah; Haining, Jessica; Johnson, Dayna; Hemida, Maged G.; Barr, Jennifer; Peiris, Malik; Middleton, Deborah; Wang, Lin-Fa

doi:10.3201/eid2206.160007

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Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus

Jun 15 2016
By Crameri, Gary ; Durr, Peter A. ; Klein, Reuben ; ...
http://dx.doi.org/10.3201/eid2206.160007
Source: Emerg Infect Dis. 22(6):1071-1074.

[PDF-736.50 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Crameri, Gary ; Durr, Peter A. ; Klein, Reuben ; Foord, Adam ; Yu, Meng ; ... More +

Crameri, Gary ; Durr, Peter A. ; Klein, Reuben ; Foord, Adam ; Yu, Meng ; Riddell, Sarah ; Haining, Jessica ; Johnson, Dayna ; Hemida, Maged G. ; Barr, Jennifer ; Peiris, Malik ; Middleton, Deborah ; Wang, Lin-Fa Less -
Description:

We conducted a challenge/rechallenge trial in which 3 alpacas were infected with Middle East respiratory syndrome coronavirus. The alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. The trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.
Subjects:

[+]

Animals Antibodies, Neutralizing Antibodies, Viral Camelids, New World Coronavirus Infections Disease Models, Animal Female Middle East Respiratory Syndrome Coronavirus Neutralization Tests Viral Load Virus Shedding
Source:

Emerg Infect Dis. 22(6):1071-1074.
Pubmed ID:

27070733
Pubmed Central ID:

PMC4880109
Document Type:

Journal Article
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:eff6286e4c029792d2104acff5d57faab704cfb9d50f6e7bd835b0080cb298ad
Download URL:

https://stacks.cdc.gov/view/cdc/39702/cdc_39702_DS1.pdf
File Type:

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	16-0007-F.jpg	jpeg
	16-0007-Techapp-s1.pdf	pdf
	16-0007.nxml	bin
	license.txt	txt

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