High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

San-Juan, Rafael; Viedma, Esther; Chaves, Fernando; Lalueza, Antonio; Fortún, Jesús; Loza, Elena; Pujol, Miquel; Ardanuy, Carmen; Morales, Isabel; de Cueto, Marina; Resino-Foz, Elena; Morales-Cartagena, Alejandra; Rico, Alicia; Romero, María P.; Orellana, María Ángeles; López-Medrano, Francisco; Fernández-Ruiz, Mario; Aguado, José María

doi:10.3201/eid2206.151709

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

Published Date:

Jun 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2206.151709 New Site Icon

Source:

Emerg Infect Dis. 22(6):1057-1066.

[PDF - 1.52 MB]

Details:

Personal Authors:

San-Juan, Rafael ; Viedma, Esther ; Chaves, Fernando ; Lalueza, Antonio ; Fortún, Jesús ; ... More ▼

Keywords:

[+]

Pubmed ID:

27192097

Pubmed Central ID:

PMC4880091

Description:

We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

15-1709-F.gif	image/gif
15-1709-F.jpg	image/jpeg
15-1709-Techapp-s1.pdf	application/pdf
15-1709.nxml	application/octet-stream
license.txt	text/plain

No Related Documents.

You May Also Like:

High Vancomycin MIC and Complicated Methicillin-Susceptible Staphylococcus aureus Bacteremia

Personal Author:

Aguado, Jose Maria; San-Juan, Rafael; Lalueza, Antonio; Sanz, Francisca; Rodríguez-Otero, Joaquin; Gómez-Gonzalez, Carmen; Chaves, Fernando;

Published:

Jun 2011

Source:

Emerg Infect Dis. 17(6):1099-1102.

Description:

We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 ug/mL) was the only independent risk factor for...

File Type:

[PDF - 212.17 KB]
Daptomycin vs. vancomycin for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA): A nested case-control study

Personal Author:

Liang, Stephen Y.; Khair, Hani N.; McDonald, Jay R.; Babcock, Hilary M.; Marschall, Jonas;

Published:

Nov 03 2013

Source:

Eur J Clin Microbiol Infect Dis. 33(4):659-664.

Description:

Purpose : Vancomycin is the standard antibiotic for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. While daptomycin is approved for MRSA bacteremia, its effectiveness in osteoarticular infections (OAI) has not been establ...

File Type:

[PDF - 117.29 KB]
Economic Evaluation and Catheter-related Bloodstream Infections

Personal Author:

Halton, Kate; Graves, Nicholas;

Published:

Jun 2007

Source:

Emerg Infect Dis. 13(6):815-823.

Description:

Catheter-related bloodstream infections are a serious problem. Many interventions reduce risk, and some have been evaluated in cost-effectiveness studies. We review the usefulness and quality of these economic studies. Evidence is incomplete, and dat...

File Type:

[PDF - 366.76 KB]
Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococci Co-colonization1

Personal Author:

Furuno, Jon P.; Perencevich, Eli N.; Johnson, Judith A.; Wright, Marc-Oliver; McGregor, Jessina C.; Morris, J. Glenn; Strauss, Sandra M.; Roghman, Mary-Claire; Nemoy, Lucia L.; Standiford, Harold C.; Hebden, Joan N.; Harris, Anthony D.;

Published:

Oct 2005

Source:

Emerg Infect Dis. 11(10):1539-1544.

Description:

We assessed the prevalence, risk factors, and clinical outcomes of patients co-colonized with vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) upon admission to the medical and surgical intensive care unit...

File Type:

[PDF - 162.87 KB]
Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococci in Rural Communities, Western United States

Personal Author:

Stevenson, Kurt B.; Searle, Katy; Stoddard, Gregory; Samore, Matthew H.;

Published:

Jun 2005

Source:

Emerg Infect Dis. 11(6):895-903.

Description:

The impact and prevalence of antimicrobial drug resistance in rural community healthcare settings is uncertain. Prospective surveillance in 51 rural hospitals in Idaho and Utah examined the epidemiologic features of clinical cases of methicillin-resi...

File Type:

[PDF - 242.76 KB]