High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

San-Juan, Rafael; Viedma, Esther; Chaves, Fernando; Lalueza, Antonio; Fortún, Jesús; Loza, Elena; Pujol, Miquel; Ardanuy, Carmen; Morales, Isabel; de Cueto, Marina; Resino-Foz, Elena; Morales-Cartagena, Alejandra; Rico, Alicia; Romero, María P.; Orellana, María Ángeles; López-Medrano, Francisco; Fernández-Ruiz, Mario; Aguado, José María

doi:10.3201/eid2206.151709

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High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

Published Date:

Jun 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2206.151709 New Site Icon

Source:

Emerg Infect Dis. 22(6):1057-1066.

[PDF-1.52 MB]

Details:

Personal Authors:

San-Juan, Rafael ; Viedma, Esther ; Chaves, Fernando ; Lalueza, Antonio ; Fortún, Jesús ; ... More ▼

Keywords:

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Pubmed ID:

27192097

Pubmed Central ID:

PMC4880091

Description:

We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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	15-1709-Techapp-s1.pdf	application/pdf
	15-1709.nxml	application/octet-stream
	license.txt	text/plain

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