Public Health Importance of Invasive Methicillin-sensitive Staphylococcus aureus Infections: Surveillance in 8 US Counties, 2016

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Jackson, Kelly A. ; Gokhale, Runa H. ; Nadle, Joelle ; Ray, Susan M. ; Dumyati, Ghinwa ; Schaffner, William ; Ham, David C. ; Magill, Shelley S. ; Lynfield, Ruth ; See, Isaac
• Description:
  Background.
  
  Public health and infection control prevention and surveillance efforts in the United States have primarily focused on methicillin-resistant Staphylococcus aureus (MRSA). We describe the public health importance of methicillin-susceptible S. aureus (MSSA) in selected communities.
  
  Methods.
  
  We analyzed Emerging Infections Program surveillance data for invasive S. aureus (SA) infections (isolated from a normally sterile body site) in 8 counties in 5 states during 2016. Cases were considered healthcare-associated if culture was obtained >3 days after hospital admission; if associated with dialysis, hospitalization, surgery, or long-term care facility (LTCF) residence within 1 year prior; or if a central venous catheter was present ≤2 days prior. Incidence per 100 000 census population was calculated, and a multivariate logistic regression model with random intercepts was used to compare MSSA risk factors with those of MRSA.
  
  Results.
  
  Invasive MSSA incidence (31.3/100 000) was 1.8 times higher than MRSA (17.5/100 000). Persons with MSSA were more likely than those with MRSA to have no underlying medical conditions (adjusted odds ratio [aOR], 2.06; 95% confidence interval [CI], 1.26–3.39) and less likely to have prior hospitalization (aOR, 0.70; 95% CI, 0.60–0.82) or LTCF residence (aOR, 0.37; 95% CI, 0.29–0.47). MSSA accounted for 59.7% of healthcare-associated cases and 60.1% of deaths.
  
  Conclusions.
  
  Although MRSA tended to be more closely associated with healthcare exposures, invasive MSSA is a substantial public health problem in the areas studied. Public health and infection control prevention efforts should consider MSSA prevention in addition to MRSA.
  
  
• Subjects:
  Humans Methicillin Methicillin-Resistant Staphylococcus Aureus Public Health Renal Dialysis Staphylococcal Infections Staphylococcus Aureus United States
• Keywords:
  Methicillin-sensitive Staphylococcus Aureus MSSA MSSA Burden
• Source:
  Clin Infect Dis. 70(6):1021-1028
• Pubmed ID:
  31245810
• Pubmed Central ID:
  PMC7902232
• Document Type:
  Journal Article
• Funding:
  U50 CK000198/CK/NCEZID CDC HHSUnited States/ ; U50 CK000199/CK/NCEZID CDC HHSUnited States/ ; U50 CK000196/CK/NCEZID CDC HHSUnited States/ ; U50 CK000201/CK/NCEZID CDC HHSUnited States/ ; U50 CK000204/CK/NCEZID CDC HHSUnited States/
• Volume:
  70
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c4c733b1391e3169f243939e2e9c72689000a031430791e00ee87e235caa0b9f94e1ea15c0db978ccf07a042dcfdfe40189b8e4c61f419318d449555437d0acd
• Download URL:
  https://stacks.cdc.gov/view/cdc/103798/cdc_103798_DS1.pdf
• File Type:
  [PDF - 398.22 KB ]