Extended Human-to-Human Transmission during a Monkeypox Outbreak in the Democratic Republic of the Congo

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nolen, Leisha Diane ; Osadebe, Lynda ; Katomba, Jacques ; Likofata, Jacques ; Mukadi, Daniel ; Monroe, Benjamin ; Doty, Jeffrey ; Hughes, Christine Marie ; Kabamba, Joelle ; Malekani, Jean ; Bomponda, Pierre Lokwa ; Lokota, Jules Inonga ; Balilo, Marcel Pie ; Likafi, Toutou ; Lushima, Robert Shongo ; Ilunga, Benoit Kebela ; Nkawa, Frida ; Pukuta, Elisabeth ; Karhemere, Stomy ; Tamfum, Jean-Jacques Muyembe ; Nguete, Beatrice ; Wemakoy, Emile Okitolonda ; McCollum, Andrea M. ; Reynolds, Mary G.
• Description:
  A 600-fold increase in monkeypox cases occurred in the Bokungu Health Zone of the Democratic Republic of the Congo during the second half of 2013; this increase prompted an outbreak investigation. A total of 104 possible cases were reported from this health zone; among 60 suspected cases that were tested, 50 (48.1%) cases were confirmed by laboratory testing, and 10 (9.6%) tested negative for monkeypox virus (MPXV) infection. The household attack rate (i.e., rate of persons living with an infected person that develop symptoms of MPXV infection) was 50%. Nine families showed >1 transmission event, and >6 transmission events occurred within this health zone. Mean incubation period was 8 days (range 4-14 days). The high attack rate and transmission observed in this study reinforce the importance of surveillance and rapid identification of monkeypox cases. Community education and training are needed to prevent transmission of MPXV infection during outbreaks.
• Subjects:
  Disease Outbreaks Disease Transmission, Infectious Monkeypox Virus Mpox (monkeypox) Mpox (monkeypox)/transmission Research
• Source:
  Emerg Infect Dis. 22(6):1014-1021.
• Pubmed ID:
  27191380
• Pubmed Central ID:
  PMC4880088
• Document Type:
  Journal Article
• Place as Subject:
  Democratic Republic of the Congo
• Volume:
  22
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:880cac6f61d1aeb9926327bfd43d39619e9a468f53058100dae1759242c6390a
• Download URL:
  https://stacks.cdc.gov/view/cdc/39674/cdc_39674_DS1.pdf
• File Type:
  [PDF - 2.01 MB ]