i
Superseded
This Document Has Been Replaced By:
i
Retired
This Document Has Been Retired
i
Up-to-date Information
This is the latest update:
Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study
-
Published Date:
Nov 11 2015
-
Publisher's site:
-
Source:Obesity (Silver Spring). 24(1):231-237.
-
Details:
-
Alternative Title:Obesity (Silver Spring)
-
Personal Author:
-
Description:Objective To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant. Methods Data are from a prospective cohort in Cincinnati, OH (HOME Study). We measured perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids in prenatal serum samples. We estimated differences in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n=204) and BMI between 2–8 years of age (n=285) according to PFAS concentrations. Results Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI:1.7, 6.9) and 3rd tercile (2.2; 95% CI:−0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2–8 years compared to children in the 1st tercile (p<0.05). PFOS, PFNA and PFHxS were not associated with adiposity. Conclusions In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2–8 years.
-
Subject:
-
Pubmed ID:26554535
-
Pubmed Central ID:PMC4688224
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
image/jpeg text/plain application/pdf application/octet-stream image/gif image/jpeg image/gif image/jpeg image/gif
No Related Documents.