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Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study
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Nov 11 2015
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Source: Obesity (Silver Spring). 24(1):231-237.
Details:
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Alternative Title:Obesity (Silver Spring)
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Personal Author:
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Description:Objective
To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.
Methods
Data are from a prospective cohort in Cincinnati, OH (HOME Study). We measured perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids in prenatal serum samples. We estimated differences in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n=204) and BMI between 2–8 years of age (n=285) according to PFAS concentrations.
Results
Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI:1.7, 6.9) and 3rd tercile (2.2; 95% CI:−0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2–8 years compared to children in the 1st tercile (p<0.05). PFOS, PFNA and PFHxS were not associated with adiposity.
Conclusions
In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2–8 years.
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Pubmed ID:26554535
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Pubmed Central ID:PMC4688224
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Volume:24
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Issue:1
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