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Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study
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Details:
  • Pubmed ID:
    26554535
  • Pubmed Central ID:
    PMC4688224
  • Description:
    Objective

    To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.

    Methods

    Data are from a prospective cohort in Cincinnati, OH (HOME Study). We measured perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids in prenatal serum samples. We estimated differences in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n=204) and BMI between 2–8 years of age (n=285) according to PFAS concentrations.

    Results

    Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI:1.7, 6.9) and 3rd tercile (2.2; 95% CI:−0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2–8 years compared to children in the 1st tercile (p<0.05). PFOS, PFNA and PFHxS were not associated with adiposity.

    Conclusions

    In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2–8 years.

  • Document Type:
  • Collection(s):
  • Funding:
    P01 ES011261/ES/NIEHS NIH HHS/United States
    P01 ES11261/ES/NIEHS NIH HHS/United States
    P30 ES006096/ES/NIEHS NIH HHS/United States
    R00 ES020 346/ES/NIEHS NIH HHS/United States
    R00 ES020346/ES/NIEHS NIH HHS/United States
    R01 ES014575/ES/NIEHS NIH HHS/United States
    R01 ES020349/ES/NIEHS NIH HHS/United States
    R01 ES020349/ES/NIEHS NIH HHS/United States
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