Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study

Braun, Joseph M.; Chen, Aimin; Romano, Megan E.; Calafat, Antonia M.; Webster, Glenys M.; Yolton, Kimberly; Lanphear, Bruce P.

doi:10.1002/oby.21258

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Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study

Published Date:

Nov 11 2015

Publisher's site:

http://dx.doi.org/10.1002/oby.21258 New Site Icon

Source:

Obesity (Silver Spring). 24(1):231-237.

[PDF-1006.86 KB]

Details:

Alternative Title:

Obesity (Silver Spring)

Personal Author:

Braun, Joseph M. ; Chen, Aimin ; Romano, Megan E. ; Calafat, Antonia M. ; Webster, Glenys M. ; ... More ▼

Description:

Objective

To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.

Methods

Data are from a prospective cohort in Cincinnati, OH (HOME Study). We measured perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids in prenatal serum samples. We estimated differences in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n=204) and BMI between 2–8 years of age (n=285) according to PFAS concentrations.

Results

Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI:1.7, 6.9) and 3rd tercile (2.2; 95% CI:−0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2–8 years compared to children in the 1st tercile (p<0.05). PFOS, PFNA and PFHxS were not associated with adiposity.

Conclusions

In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2–8 years.

Subject:

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Pubmed ID:

26554535

Pubmed Central ID:

PMC4688224

Document Type:

Journal Article

Funding:

P01 ES011261/ES/NIEHS NIH HHS/United States ; P01 ES11261/ES/NIEHS NIH HHS/United States ; P30 ES006096/ES/NIEHS NIH HHS/United States ; R00 ES020 346/ES/NIEHS NIH HHS/United States ; R00 ES020346/ES/NIEHS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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