Endocrine Disrupting Chemicals, Transgenerational Epigenetics and Metabolic Diseases

Details

• Alternative Title:
  EC Endocrinol Metab Res
• Personal Author:
  Feroe, Aliya ; Broene, Richard ; Albuquerque, David ; Ruiz, Patricia
• Description:
  Exposure to environmental chemicals can produce effects on the endocrine system through epigenetic mechanisms. These can considerably decrease or increase the sensitivity of multiple hormones depending on the dose, route, or time of exposure. The exposure of endocrine disrupting chemicals (EDCs) during the | period could be a critical window, altering the epigenome profile. Recently, several researchers suggest a role of EDCs in the obesity epidemic. In this brief review, we focused on how four EDCs (bisphenol A, dichlorodiphenyltrichloroethane, di-(2-ethylhexyl) phthalate and tributyltin) may underlay transgenerational epigenetic effects. We also discuss the adipogenesis signaling pathway and the impact of exposure to individual or mixtures of EDCs on the developing endocrine system. Understanding the molecular determinants of epigenetic memory across generations will provide essential insight into how environmental exposure can affect the health of individuals, as well as subsequent generations.
• Keywords:
  Endocrine Disrupting Chemicals Epigenetics In Utero Obesity Obesogen
• Source:
  EC Endocrinol Metab Res. 21:31-51
• Pubmed ID:
  34734213
• Pubmed Central ID:
  PMC8563023
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  21
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a8e5c3ca5a0809b509e2d628017e7842b33b1ce3e4965d76cce75a8304b79fe7d6c70e1d7cd41acb2d48ee54d45c4148b4c72506344c7a0b90410a16cf5bcf0a
• Download URL:
  https://stacks.cdc.gov/view/cdc/111331/cdc_111331_DS1.pdf
• File Type:
  [PDF - 991.80 KB ]