Risk of pancreatic cancer in female textile workers in Shanghai, China exposed to metals, solvents, chemicals, and endotoxin: follow-up to a nested case-cohort study

Reul, Nicholas K.; Li, Wenjin; Gallagher, Lisa G.; Ray, Roberta M.; Romano, Megan E.; Gao, Daoli; Thomas, David B.; Vedal, Sverre; Checkoway, Harvey

doi:10.1097/JOM.0000000000000596

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Risk of pancreatic cancer in female textile workers in Shanghai, China exposed to metals, solvents, chemicals, and endotoxin: follow-up to a nested case-cohort study

2 2016
By Reul, Nicholas K. ; Li, Wenjin ; Gallagher, Lisa G. ; ...
http://dx.doi.org/10.1097/JOM.0000000000000596
Source: J Occup Environ Med. 58(2):195-199

[PDF-120.79 KB]

English

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Details:

Alternative Title:

J Occup Environ Med
Personal Author:

Reul, Nicholas K. ; Li, Wenjin ; Gallagher, Lisa G. ; Ray, Roberta M. ; Romano, Megan E. ; ... More +

Reul, Nicholas K. ; Li, Wenjin ; Gallagher, Lisa G. ; Ray, Roberta M. ; Romano, Megan E. ; Gao, Daoli ; Thomas, David B. ; Vedal, Sverre ; Checkoway, Harvey Less -
Description:

Objective

We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously-studied cohort.

Methods

We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly-selected subcohort of 3191 non-cases. We calculated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards modeling adapted for the case-cohort design.

Results

We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.

Conclusions

Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
Keywords:

[+]

Case-Control Studies China Endotoxins Environmental Pollutants Female Follow-Up Studies Humans Metals Occupational Diseases Occupational Exposure Pancreatic Neoplasms Proportional Hazards Models Risk Factors Solvents Textile Industry
Source:

J Occup Environ Med. 58(2):195-199
Pubmed ID:

26849264
Pubmed Central ID:

PMC4870312
Document Type:

Journal Article
Funding:

T42 OH008433/OH/NIOSH CDC HHSUnited States/ ; R01 CA080180/CA/NCI NIH HHSUnited States/ ; T42OH008433/OH/NIOSH CDC HHSUnited States/ ; T42OH008433/ACL/ACL HHSUnited States/ ; R01CA80180/CA/NCI NIH HHSUnited States/

T42 OH008433/OH/NIOSH CDC HHSUnited States/ ; R01 CA080180/CA/NCI NIH HHSUnited States/ ; T42OH008433/OH/NIOSH CDC HHSUnited States/ ; T42OH008433/ACL/ACL HHSUnited States/ ; R01CA80180/CA/NCI NIH HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:d7944a9dbf533e7fa88fadd51468d7975e2a856738bffc764598e1015009a563
Download URL:

https://stacks.cdc.gov/view/cdc/39522/cdc_39522_DS1.pdf
File Type:

nihms722930.nxml

xml

More +