Risk of pancreatic cancer in female textile workers in Shanghai, China exposed to metals, solvents, chemicals, and endotoxin: follow-up to a nested case-cohort study
Published Date:Feb 2016
Source:J Occup Environ Med. 58(2):195-199.
Pubmed Central ID:PMC4870312
Funding:R01 CA080180/CA/NCI NIH HHS/United States
T42 OH008433/OH/NIOSH CDC HHS/United States
R01CA80180/CA/NCI NIH HHS/United States
T42OH008433/OH/NIOSH CDC HHS/United States
We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously-studied cohort.
We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly-selected subcohort of 3191 non-cases. We calculated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards modeling adapted for the case-cohort design.
We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.
Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.
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