Risk of pancreatic cancer in female textile workers in Shanghai, China, exposed to metals, solvents, chemicals, and endotoxin: follow-up to a nested case-cohort study

Details

• Personal Author:
  Checkoway, Harvey ; Gallagher LG ; Gao D ; Li W ; Ray RM ; Reul NK ; Romano ME ; Thomas DB ; Vedal S
• Description:
  Objective: We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort. Methods: We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design. Results: We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals. Conclusions: Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endotoxins Metals Neoplasms Occupational Exposure Occupational Health Safety Solvents Textile Industry Women
• Keywords:
  Cancer Rates Cohort Studies Exposure Assessment JEM Job Exposure Matrix Occupational Exposure Textile Mills Textile Workers
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  195-199
• Volume:
  58
• Issue:
  2
• NIOSHTIC Number:
  nn:20047425
• Citation:
  J Occup Environ Med 2016 Feb; 58(2):195-199
• Contact Point Address:
  Nicholas K. Reul, MD, MPH, Department of Occupational and Environmental Medicine, University of Washington, Box 359739, 325 9th Avenue, Seattle, WA 98104
• Email:
  nreul@uw.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:99724808d917ffbbe608118475d9a654510146bb2531f19fb7e6addb369ddafd60f40e0e3520cc3dd47c93ec3891fb7b2bc23b7b5251b8eccd31f0770b37378d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202488/cdc_202488_DS1.pdf
• File Type:
  [PDF - 138.37 KB ]