Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2016.02.002
Personal Author:
Ma, Chao; Gregory, Christopher J.; Hao, Lixin; Wannemuehler, Kathleen A.; Su, Qiru; ... More +
Ma, Chao; Gregory, Christopher J.; Hao, Lixin; Wannemuehler, Kathleen A.; Su, Qiru; An, Zhijie; Quick, Linda; Rodewald, Lance; Ma, Fubao; Yan, Rui; Song, Lizhi; Zhang, Yanyang; Kong, Yi; Zhang, Xiaoshu; Wang, Huaqing; Li, Li; Cairns, Lisa; Wang, Ning; Luo, Huiming; Less -
Description:
Introduction: Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. We performed a case–control study in six Chinese provinces during January 2012 through June 2013 to identify risk factors for measles infection among children aged 0–7 months. Methods: Children with laboratory-confirmed measles were neighborhood matched with three controls. We interviewed parents of case and control infants on potential risk factors for measles. Adjusted matched odds ratios (mOR) and 95% confidence intervals (CIs) were calculated by multivariable conditional logistic modeling. We calculated attributable fractions for risk factors that could be interpreted as causal. Results: Eight hundred thirty cases and 2303 controls were enrolled. In multivariable analysis, male sex (mOR 1.6 [1.3, 2.0]), age 5–7 months (mOR 3.9 [3.0, 5.1]), migration between counties (mOR 2.3 [1.6, 3.4]), outpatient hospital visits (mOR 9.4 [6.6, 13.3]) and inpatient hospitalization (mOR 107.1 [48.8, 235.1]) were significant risk factors. The calculated attributable fractions for hospital visits was 43.1% (95% CI: 40.1, 47.5%) adjusted for age, sex and migration. Conclusions: Hospital visitation was the largest risk factor for measles infection in infants. Improved hospital infection control practices would accelerate measles elimination in China.
Subject:
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Article
Case-Control Studies
Female
Humans
Infant
Infant, Newborn
Male
Measles
Risk Factors

Source:
Vaccine. 34(51):6553-6560;
Pubmed ID:
27013438
Pubmed Central ID:
PMC6524948
Document Type:
Journal Article;
Funding:
001/World Health Organization/International; CC999999/Intramural CDC HHS/United States;
001/World Health Organization/International; CC999999/Intramural CDC HHS/United States; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f7bcee4200fcdc781f2e837baab2343a08dec682a55e205f49789c528da58d6f
File Type:

Supporting Files

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