Details:

Alternative Title:
Vaccine
Personal Author:
Ma, Chao ; Gregory, Christopher J. ; Hao, Lixin ; Wannemuehler, Kathleen A. ; Su, Qiru ; ... More +
Ma, Chao ; Gregory, Christopher J. ; Hao, Lixin ; Wannemuehler, Kathleen A. ; Su, Qiru ; An, Zhijie ; Quick, Linda ; Rodewald, Lance ; Ma, Fubao ; Yan, Rui ; Song, Lizhi ; Zhang, Yanyang ; Kong, Yi ; Zhang, Xiaoshu ; Wang, Huaqing ; Li, Li ; Cairns, Lisa ; Wang, Ning ; Luo, Huiming Less -
Description:
Introduction:

Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. We performed a case–control study in six Chinese provinces during January 2012 through June 2013 to identify risk factors for measles infection among children aged 0–7 months.

Methods:

Children with laboratory-confirmed measles were neighborhood matched with three controls. We interviewed parents of case and control infants on potential risk factors for measles. Adjusted matched odds ratios (mOR) and 95% confidence intervals (CIs) were calculated by multivariable conditional logistic modeling. We calculated attributable fractions for risk factors that could be interpreted as causal.

Results:

Eight hundred thirty cases and 2303 controls were enrolled. In multivariable analysis, male sex (mOR 1.6 [1.3, 2.0]), age 5–7 months (mOR 3.9 [3.0, 5.1]), migration between counties (mOR 2.3 [1.6, 3.4]), outpatient hospital visits (mOR 9.4 [6.6, 13.3]) and inpatient hospitalization (mOR 107.1 [48.8, 235.1]) were significant risk factors. The calculated attributable fractions for hospital visits was 43.1% (95% CI: 40.1, 47.5%) adjusted for age, sex and migration.

Conclusions:

Hospital visitation was the largest risk factor for measles infection in infants. Improved hospital infection control practices would accelerate measles elimination in China.


Subjects:
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Case-Control Studies Female Humans Infant Infant, Newborn Male Risk Factors
Keywords:
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Case–control Study Measles Measles Elimination Population Immunity Risk Factors
Source:
Vaccine. 34(51):6553-6560
Pubmed ID:
27013438
Pubmed Central ID:
PMC6524948
Document Type:
Journal Article
Funding:
001/WHO_/World Health OrganizationInternational/ ; CC999999/Intramural CDC HHSUnited States/
001/WHO_/World Health OrganizationInternational/ ; CC999999/Intramural CDC HHSUnited States/ Less -
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f7bcee4200fcdc781f2e837baab2343a08dec682a55e205f49789c528da58d6f
Download URL:
https://stacks.cdc.gov/view/cdc/78553/cdc_78553_DS1.pdf
File Type:

Supporting Files

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