Risk factors for measles infection in 0–7 month old children in China after the 2010 nationwide measles campaign: A multi-site case–control study, 2012–2013☆

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Ma, Chao ; Gregory, Christopher J. ; Hao, Lixin ; Wannemuehler, Kathleen A. ; Su, Qiru ; An, Zhijie ; Quick, Linda ; Rodewald, Lance ; Ma, Fubao ; Yan, Rui ; Song, Lizhi ; Zhang, Yanyang ; Kong, Yi ; Zhang, Xiaoshu ; Wang, Huaqing ; Li, Li ; Cairns, Lisa ; Wang, Ning ; Luo, Huiming
• Description:
  Introduction:
  
  Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. We performed a case–control study in six Chinese provinces during January 2012 through June 2013 to identify risk factors for measles infection among children aged 0–7 months.
  
  Methods:
  
  Children with laboratory-confirmed measles were neighborhood matched with three controls. We interviewed parents of case and control infants on potential risk factors for measles. Adjusted matched odds ratios (mOR) and 95% confidence intervals (CIs) were calculated by multivariable conditional logistic modeling. We calculated attributable fractions for risk factors that could be interpreted as causal.
  
  Results:
  
  Eight hundred thirty cases and 2303 controls were enrolled. In multivariable analysis, male sex (mOR 1.6 [1.3, 2.0]), age 5–7 months (mOR 3.9 [3.0, 5.1]), migration between counties (mOR 2.3 [1.6, 3.4]), outpatient hospital visits (mOR 9.4 [6.6, 13.3]) and inpatient hospitalization (mOR 107.1 [48.8, 235.1]) were significant risk factors. The calculated attributable fractions for hospital visits was 43.1% (95% CI: 40.1, 47.5%) adjusted for age, sex and migration.
  
  Conclusions:
  
  Hospital visitation was the largest risk factor for measles infection in infants. Improved hospital infection control practices would accelerate measles elimination in China.
  
  
• Subjects:
  Case-Control Studies China Female Humans Infant Infant, Newborn Male Measles Risk Factors
• Keywords:
  Case–control Study Measles Elimination Population Immunity Risk Factors
• Source:
  Vaccine. 34(51):6553-6560
• Pubmed ID:
  27013438
• Pubmed Central ID:
  PMC6524948
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/Intramural CDC HHSUnited States/
• Volume:
  34
• Issue:
  51
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:18ff63814619622529551399648eeb566b61fef566e52114592f83e9fdd4f0c9dc4306f29d8ce6d892d5d50e3510887ba5f14f58bc6033b9f63ea32f1d508b63
• Download URL:
  https://stacks.cdc.gov/view/cdc/78553/cdc_78553_DS1.pdf
• File Type:
  [PDF - 636.52 KB ]