Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2204.150455
Personal Author:
Durham, David P. ; Olsen, Margaret A. ; Dubberke, Erik R. ; Galvani, Alison P. ; Townsend, Jeffrey P. ;
Durham, David P. ; Olsen, Margaret A. ; Dubberke, Erik R. ; Galvani, Alison P. ; Townsend, Jeffrey P. ; Less -
Description:
To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.
Subject:
[+]
Asymptomatic Infections
Bacteria
Clostridium Difficile
Community-acquired Infections
Healthcare Settings
Hospital Infections
Nosocomial Infections
Quantifying Transmission Of Clostridium Difficile Within And Outside Healthcare Settings
Research
Theoretical Models
Transmission

Source:
Emerg Infect Dis. 22(4):608-616. ;
Pubmed ID:
26982504
Pubmed Central ID:
PMC4806959
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3d6bde7d1d8563637fca936f7b38a570e10976bdc44960c9a25bf99daebde92d
File Type:

Supporting Files

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