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Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings
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Apr 2016
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Source: Emerg Infect Dis. 22(4):608-616.
[PDF-619.06 KB]
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Alternative Title:Emerg Infect Dis
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Description:To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.
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Pubmed ID:26982504
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Pubmed Central ID:PMC4806959
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Document Type:
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Volume:22
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Issue:4
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