Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings

Durham, David P.; Olsen, Margaret A.; Dubberke, Erik R.; Galvani, Alison P.; Townsend, Jeffrey P.

doi:10.3201/eid2204.150455

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Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings

Published Date:

Apr 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2204.150455

Source:

Emerg Infect Dis. 22(4):608-616.

[PDF-619.06 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Durham, David P. ; Olsen, Margaret A. ; Dubberke, Erik R. ; Galvani, Alison P. ; Townsend, Jeffrey P. ;

Description:

To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.

Subject:

[+]

Pubmed ID:

26982504

Pubmed Central ID:

PMC4806959

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

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