Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings

Durham, David P.; Olsen, Margaret A.; Dubberke, Erik R.; Galvani, Alison P.; Townsend, Jeffrey P.

doi:10.3201/eid2204.150455

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings

Published Date:

Apr 2016

Publisher's site:

http://dx.doi.org/10.3201/eid2204.150455 New Site Icon

Source:

Emerg Infect Dis. 22(4):608-616.

[PDF-619.06 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Durham, David P. ; Olsen, Margaret A. ; Dubberke, Erik R. ; Galvani, Alison P. ; Townsend, Jeffrey P. ;

Description:

To quantify the effect of hospital and community-based transmission and control measures on Clostridium difficile infection (CDI), we constructed a transmission model within and between hospital, community, and long-term care-facility settings. By parameterizing the model from national databases and calibrating it to C. difficile prevalence and CDI incidence, we found that hospitalized patients with CDI transmit C. difficile at a rate 15 (95% CI 7.2-32) times that of asymptomatic patients. Long-term care facility residents transmit at a rate of 27% (95% CI 13%-51%) that of hospitalized patients, and persons in the community at a rate of 0.1% (95% CI 0.062%-0.2%) that of hospitalized patients. Despite lower transmission rates for asymptomatic carriers and community sources, these transmission routes have a substantial effect on hospital-onset CDI because of the larger reservoir of hospitalized carriers and persons in the community. Asymptomatic carriers and community sources should be accounted for when designing and evaluating control interventions.

Subject:

[+]

Pubmed ID:

26982504

Pubmed Central ID:

PMC4806959

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	15-0455-Techapp-s1.pdf	application/pdf
	15-0455.nxml	application/octet-stream
	license.txt	text/plain
	15-0455-F1.gif	image/gif
	15-0455-F1.jpg	image/jpeg
	15-0455-F2.gif	image/gif
	15-0455-F2.jpg	image/jpeg
	15-0455-F3.gif	image/gif
	15-0455-F3.jpg	image/jpeg
	15-0455-F4.gif	image/gif
	15-0455-F4.jpg	image/jpeg

No Related Documents.

You May Also Like:

EPIDEMIOLOGICAL MODEL FOR CLOSTRIDIUM DIFFICILE TRANSMISSION IN HEALTH-CARE SETTINGS

Personal Author:

Lanzas, C.; Dubberke, E.R.; Lu, Z.; Reske, K.A.; Gröhn, Y.T.;

Published Date:

Jun 2011

Source:

Infect Control Hosp Epidemiol. 32(6):553-561.

Description:

ObjectiveRecent outbreaks of Clostridium difficile infection (CDI) have been difficult to control, and data indicate the importance of different sources of transmission may have changed. Our objectives were to evaluate the contributions of asymptomat...

File Type:

[PDF - 683.35 KB]
Challenges and Strategies for Prevention of Multidrug-Resistant Organism Transmission in Nursing Homes

Personal Author:

Dumyati, Ghinwa; Stone, Nimalie D.; Nace, David A.; Crnich, Christopher J.; Jump, Robin L. P.;

Published Date:

Apr 2017

Source:

Curr Infect Dis Rep. 19(4).

Description:

Purpose of ReviewNursing home residents are at high risk for colonization and infection with bacterial pathogens that are multidrug-resistant organisms (MDROs). We discuss challenges and potential solutions to support implementing effective infection...

File Type:

[PDF - 341.00 KB]
Options for evaluating environmental cleaning

Personal Author:

Guh, Alice; Carling, Philip;

Corporate Authors:

National Center for Emerging and Zoonotic Infectious Diseases (U.S.). Division of Healthcare Quality Promotion.

Published Date:

October 2010

Description:

In view of the evidence that transmission of many healthcare acquired pathogens (HAPs) is related to contamination of near-patient surfaces and equipment, all hospitals are encouraged to develop programs to optimize the thoroughness of high touch sur...

File Type:

[PDF - 330.91 KB]
Causes, Burden, and Prevention of Clostridium difficile Infection

Personal Author:

Gould, Carolyn V.; File, Thomas M.; McDonald, L. Clifford;

Published Date:

May 2015

Source:

Infect Dis Clin Pract (Baltim Md). 23(6):281-288

Description:

infection (CDI) is a potentially deadly cause of diarrhea that is virtually always connected to healthcare system exposures, both inpatient and outpatient. Once a disease mainly of hospitals, 75% of CDI cases are now diagnosed outside of hospitals. H...

File Type:

[PDF - 413.40 KB]
A Public health action plan to combat antimicrobial resistance

Corporate Authors:

United States, Interagency Task Force on Antimicrobial Resistance.. Centers for Disease Control and Prevention (U.S.). National Institutes of Health (U.S.). United States, Food and Drug Administration..

Published Date:

2011

Description:

In 2001, the Task Force developed an initial Action Plan, outlining specific issues, goals, and actions important for addressing the problem of AR. This document, entitled A Public Health Action Plan to Combat Antimicrobial Resistance, Part I: Domest...

File Type:

[PDF - 3.52 MB]