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Why build whole-cell models?
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  1. Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models
    Personal Author:
    Karr, Jonathan R.; Williams, Alex H.; Zucker, Jeremy D.; Raue, Andreas; Steiert, Bernhard; Timmer, Jens; Kreutz, Clemens; Wilkinson, Simon; Allgood, Brandon A.; Bot, Brian M.; Hoff, Bruce R.; Kellen, Michael R.; Covert, Markus W.; Stolovitzky, Gustavo A.; Meyer, Pablo;
    Corporate Author:
    DREAM8 Parameter Estimation Challenge Consortium
    Published:
    May 28 2015
    Source:
    PLoS Comput Biol. 2015; 11(5).
    Description:
    Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which...
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  2. Bioinformatic Analyses of Whole-Genome Sequence Data in a Public Health Laboratory
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    Source:
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    The ability to generate high-quality sequence data in a public health laboratory enables the identification of pathogenic strains, the determination of relatedness among outbreak strains, and the analysis of genetic information regarding virulence an...
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    The Whole School, Whole Community, Whole Child (WSCC) model expands on the eight elements of CDC’s coordinated school health ( CSH ) approach and is combined with the whole child framework. CDC and ASCD developed this expanded model—in collaborat...
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  5. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
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    Ford, Christopher B.; Lin, Philana Ling; Chase, Michael; Shah, Rupal R.; Iartchouk, Oleg; Galagan, James; Mohaideen, Nilofar; Ioerger, Thomas R.; Sacchettini, James C.; Lipsitch, Marc; Flynn, JoAnne L.; Fortune, Sarah M.;
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    Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We used whole-genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomol...
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