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Why build whole-cell models?
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  1. Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models
    Personal Author:
    Karr, Jonathan R.; Williams, Alex H.; Zucker, Jeremy D.; Raue, Andreas; Steiert, Bernhard; Timmer, Jens; Kreutz, Clemens; Wilkinson, Simon; Allgood, Brandon A.; Bot, Brian M.; Hoff, Bruce R.; Kellen, Michael R.; Covert, Markus W.; Stolovitzky, Gustavo A.; Meyer, Pablo;
    Corporate Author:
    DREAM8 Parameter Estimation Challenge Consortium
    Published:
    May 28 2015
    Source:
    PLoS Comput Biol. 2015; 11(5).
    Description:
    Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which...
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  2. Bioinformatic Analyses of Whole-Genome Sequence Data in a Public Health Laboratory
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    Oakeson, Kelly F.; Wagner, Jennifer Marie; Mendenhall, Michelle; Rohrwasser, Andreas; Atkinson-Dunn, Robyn;
    Published:
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    Source:
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    The ability to generate high-quality sequence data in a public health laboratory enables the identification of pathogenic strains, the determination of relatedness among outbreak strains, and the analysis of genetic information regarding virulence an...
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  3. Stories to reach, teach, and heal : a guide for diabetes health educators
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    National Center for Chronic Disease Prevention and Health Promotion (U.S.). Division of Diabetes Translation.
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    "Stories to reach, teach, and heal: a guide for diabetes health educators was written with the hope that sharing stories can build connections on paths toward wellness, especially for people affected by diabetes. Throughout this publication, we show ...
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  4. Whole School, Whole Community, Whole Child : a collaborative approach to learning and health
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    The Whole School, Whole Community, Whole Child (WSCC) model expands on the eight elements of CDC’s coordinated school health ( CSH ) approach and is combined with the whole child framework. CDC and ASCD developed this expanded model—in collaborat...
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  5. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
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    Ford, Christopher B.; Lin, Philana Ling; Chase, Michael; Shah, Rupal R.; Iartchouk, Oleg; Galagan, James; Mohaideen, Nilofar; Ioerger, Thomas R.; Sacchettini, James C.; Lipsitch, Marc; Flynn, JoAnne L.; Fortune, Sarah M.;
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    Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We used whole-genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomol...
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