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The Future of Whole-Cell Modeling
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    Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine--once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community.

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    5DP1LM011510-05/DP/NCCDPHP CDC HHS/United States
    DP1 LM011510/LM/NLM NIH HHS/United States
    DP1 OD006413/OD/NIH HHS/United States
    P50 GM107615/GM/NIGMS NIH HHS/United States
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