The Future of Whole-Cell Modeling

Macklin, Derek N.; Ruggero, Nicholas A.; Covert, Markus W.

doi:10.1016/j.copbio.2014.01.012

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The Future of Whole-Cell Modeling

Published Date:

Feb 17 2014

Publisher's site:

http://dx.doi.org/10.1016/j.copbio.2014.01.012

Source:

Curr Opin Biotechnol. 2014; 28:111-115.

[PDF-333.93 KB]

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Alternative Title:

Curr Opin Biotechnol

Personal Author:

Macklin, Derek N. ; Ruggero, Nicholas A. ; Covert, Markus W. ;

Description:

Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine--once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community.

Subject:

[+]

Pubmed ID:

24556244

Pubmed Central ID:

PMC4111988

Document Type:

Journal Article

Funding:

5DP1LM011510-05/DP/NCCDPHP CDC HHS/United States ; DP1 LM011510/LM/NLM NIH HHS/United States ; DP1 OD006413/OD/NIH HHS/United States ; P50 GM107615/GM/NIGMS NIH HHS/United States ;

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CDC Public Access

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Supporting Files:

	nihms568302.nxml	application/octet-stream
	nihms568302f1.gif	image/gif
	nihms568302f1.jpg	image/jpeg

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