Uptake of oral rotavirus vaccine and timeliness of routine immunization in Brazil’s National Immunization Program

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Flannery, Brendan ; Samad, Samia ; de Moraes, José Cássio ; Tate, Jacqueline E. ; Danovaro-Holliday, M. Carolina ; de Oliveira, Lúcia Helena ; Rainey, Jeanette J.
• Description:
  Introduction
  
  In March, 2006, oral rotavirus vaccine was added to Brazil’s infant immunization schedule with recommended upper age limits for initiating (by age 14 weeks) and completing (by age 24 weeks) the two-dose series to minimize age-specific risk of intussusception following rotavirus vaccination. Several years after introduction, estimated coverage with rotavirus vaccine (83%) was lower compared to coverage for other recommended childhood immunizations (≥94%).
  
  Methods
  
  We analyzed data from Brazil’s national immunization program on uptake of oral rotavirus vaccine by geographic region and compared administrative coverage estimates for first and second doses of oral rotavirus vaccine (Rota1 and Rota2) with first and second doses of diphtheria-tetanus-pertussis-Haemophilus influenzae type b vaccine (DTP-Hib1 and DTP-Hib2). For 27 Brazilian cities, we compared differences between estimated rotavirus and DTP-Hib coverage in 2010 with delayed receipt of DTP-Hib vaccine among a cohort of children surveyed before rotavirus introduction.
  
  Results
  
  In 2010, infant vaccination coverage was 99.0% for DTP-Hib1 versus 95.2% for Rota1 (3.8% difference), and 98.4% for DTP-Hib2 versus 83.0% for Rota2 (15.4% difference), with substantial regional variation. Differences between DTP-Hib and rotavirus vaccination coverage in Brazilian cities correlated with delay in DTP-Hib vaccination among children surveyed. Age restrictions for initiating and completing the rotavirus vaccination series likely contributed to lower coverage with rotavirus vaccine in Brazil.
  
  Conclusion
  
  To maximize benefits of rotavirus vaccination, strategies are needed to improve timeliness of routine immunizations; monitoring rotavirus vaccine uptake and intussusception risk is needed to guide further recommendations for rotavirus vaccination.
  
  
• Subjects:
  Article Child, Preschool Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Influenzae Haemophilus Vaccines Humans Immunization Programs Immunization Schedule Infant Male Membrane Glycoproteins Rotavirus Vaccines Vaccination

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• Source:
  Vaccine. 31(11):1523-1528.
• Pubmed ID:
  23313652
• Pubmed Central ID:
  PMC4758463
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Brazil
• Volume:
  31
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ebdf7968641f318194db721f1caa2bb17a1458a605b9f6602a598c1fdbdd772e
• Download URL:
  https://stacks.cdc.gov/view/cdc/38091/cdc_38091_DS1.pdf
• File Type:
  [PDF - 1.05 MB ]