Estimated Impact of Rotavirus Vaccine on Hospitalizations and Deaths from Rotavirus Diarrhea among Children <5 in Asia

Details

• Alternative Title:
  Expert Rev Vaccines
• Personal Author:
  Burnett, Eleanor ; Tate, Jacqueline E. ; Kirkwood, Carl D. ; Nelson, E. Anthony S. ; Santosham, Mathuram ; Steele, A. Duncan ; Parashar, Umesh D.
• Description:
  Objectives
  
  Of the 215,000 global deaths from rotavirus estimated in 2013, 41% occur in Asian countries. However, despite a recommendation for global rotavirus vaccination since 2009, only eight countries in Asia have introduced rotavirus vaccine into their national immunization program as of September 2017. To help policy makers assess the potential value of vaccination, we projected the reduction in rotavirus hospitalizations and deaths following a hypothetical national introduction of rotavirus vaccines in all countries in Asia using data on national-level rotavirus mortality, <5 population, rotavirus hospitalizations rates, routine vaccination coverage, and vaccine effectiveness.
  
  Methods
  
  To quantify uncertainty, we generated 1,000 simulations of these inputs.
  
  Results
  
  Our model predicted 710,000 fewer rotavirus hospitalizations, a 49% decrease from the 1,452,000 baseline hospitalizations and 35,000 fewer rotavirus deaths, a 40% decrease from the 88,000 baseline deaths if all 43 Asian countries had introduced rotavirus vaccine. Similar reductions were projected in subanalyses by vaccine introduction status, subregion, and birth cohort size.
  
  Conclusion
  
  Rotavirus vaccines will substantially reduce morbidity and mortality due to rotavirus infections in Asia.
  
  
• Subjects:
  Asia Child, Preschool Computer Simulation Diarrhea Hospitalization Humans Immunization Programs Models, Statistical Rotavirus Infections Rotavirus Vaccines Vaccination

  More +
• Keywords:
  Diarrhea Mortality Rotavirus Rotavirus Vaccines Routine Vaccination
• Source:
  Expert Rev Vaccines. 17(5):453-460
• Pubmed ID:
  29463143
• Pubmed Central ID:
  PMC5984136
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  17
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:95c6430486888e504b57f6cd1b4449fde254556eb9b1bef9ce77a3d5197f1b3b59f0dc3042ac0388ea2f05deefa2654f67fd4c57ae022321e0cd7b30dc39ce89
• Download URL:
  https://stacks.cdc.gov/view/cdc/55389/cdc_55389_DS1.pdf
• File Type:
  [PDF - 273.19 KB ]