Details:

Alternative Title:
Expert Rev Vaccines
Personal Author:
Burnett, Eleanor; Tate, Jacqueline E.; Kirkwood, Carl D.; Nelson, E. Anthony S.; Santosham, Mathuram; ... More +
Burnett, Eleanor; Tate, Jacqueline E.; Kirkwood, Carl D.; Nelson, E. Anthony S.; Santosham, Mathuram; Steele, A. Duncan; Parashar, Umesh D.; Less -
Description:
Objectives Of the 215,000 global deaths from rotavirus estimated in 2013, 41% occur in Asian countries. However, despite a recommendation for global rotavirus vaccination since 2009, only eight countries in Asia have introduced rotavirus vaccine into their national immunization program as of September 2017. To help policy makers assess the potential value of vaccination, we projected the reduction in rotavirus hospitalizations and deaths following a hypothetical national introduction of rotavirus vaccines in all countries in Asia using data on national-level rotavirus mortality, <5 population, rotavirus hospitalizations rates, routine vaccination coverage, and vaccine effectiveness. Methods To quantify uncertainty, we generated 1,000 simulations of these inputs. Results Our model predicted 710,000 fewer rotavirus hospitalizations, a 49% decrease from the 1,452,000 baseline hospitalizations and 35,000 fewer rotavirus deaths, a 40% decrease from the 88,000 baseline deaths if all 43 Asian countries had introduced rotavirus vaccine. Similar reductions were projected in subanalyses by vaccine introduction status, subregion, and birth cohort size. Conclusion Rotavirus vaccines will substantially reduce morbidity and mortality due to rotavirus infections in Asia.
Subject:
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Child, Preschool
Computer Simulation
Diarrhea
Hospitalization
Humans
Immunization Programs
Models, Statistical
Rotavirus Infections
Rotavirus Vaccines
Vaccination

Source:
Expert Rev Vaccines. 17(5):453-460;
Pubmed ID:
29463143
Pubmed Central ID:
PMC5984136
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Place as Subject:
Asia;
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:c19332311cd2f6863b1fc4c13613d8e6dee7babb6dace38453d093de66c488f4
File Type:

Supporting Files

• 	NIHMS946316-supplement-supplement_1.pdf	pdf
  	nihms946316.nxml	xml
  	nihms946316f1.gif	gif
  	nihms946316f1.jpg	jpeg

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