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Diacetyl and 2,3-pentanedione exposure of human cultured airway epithelial cells: Ion transport effects and metabolism of butter flavoring agents
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  1. Models of Toxicity of Diacetyl and Alternative Diones
    Personal Author:
    Brass, David M.; Palmer, Scott M.;
    Published Date:
    Feb 21 2017
    Source:
    Toxicology. 388:15-20.
    Description:
    Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH|CO)| is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient...
    File Type:
    Filetype[PDF - 320.43 KB]
  2. POPCORN FLAVORING EFFECTS ON REACTIVITY OF RAT AIRWAYS IN VIVO AND IN VITRO
    Personal Author:
    Zaccone, Eric J.; Thompson, Janet A.; Ponnoth, Dovenia S.; Cumpston, Amy M.; Goldsmith, W. Travis; Jackson, Mark C.; Kashon, Michael L.; Frazer, David G.; Hubbs, Ann F.; Shimko, Michael J.; Fedan, Jeffrey S.;
    Published Date:
    2013
    Source:
    J Toxicol Environ Health A. 76(11):669-689.
    Description:
    "Popcorn workers' lung" is an obstructive pulmonary disease produced by inhalation of volatile artificial butter flavorings. In rats, inhalation of diacetyl, a major component of butter flavoring, and inhalation...
    File Type:
    Filetype[PDF - 1.33 MB]
  3. Evaluation of the hypersensitivity potential of alternative butter flavorings
    Personal Author:
    Anderson, Stacey E.; Franko, Jennifer; Wells, J.R.; Lukomska, Ewa; Meade, B. Jean;
    Published Date:
    Sep 02 2013
    Source:
    Food Chem Toxicol. 62:373-381.
    Description:
    Concern has been raised over the association of diacetyl with lung disease clinically resembling bronchiolitis obliterans in food manufacturing workers. This has resulted in the need for identification of alternative chemicals to be used in the manuf...
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    Filetype[PDF - 1.55 MB]
  4. Occupational exposure to diacetyl and 2,3-pentanedione
    Personal Author:
    McKernan, Lauralynn T.; Niemeier, R. Todd; Kreiss, Kathleen; Hubbs Ann F.; Park, Robert; Dankovic, David A.; Dunn, Kevin H.; Parker, Jay A.; Fedan, Kathleen B.; Streicher, Robert P.; Fedan, Jeffery S.; Garcia, Alberto; Whittaker, Christine; Gilbert, Stephen J.; Nourian, Fariba; Galloway, Ellen; Smith, Randall; Lentz, Thomas J.; Hirst, Deborah V. L.; Topmiller, Jennifer L.; Curwin, Brian D.;
    Corporate Authors:
    National Institute for Occupational Safety and Health.
    Published Date:
    October 2016
    Series:
    Criteria for a recommended standard
    DHHS publication ; no. (NIOSH) 2016-111
    Description:
    This criteria document is derived from the NIOSH evaluation of critical health effects studies of occupational exposure to diacetyl and 2,3-pentanedione. It provides recommendations for controlling workplace exposures including recommended exposure l...
    Status:
    current
    File Type:
    Filetype[PDF - 37.38 MB]
  5. Recognizing occupational effects of diacetyl: What can we learn from this history?
    Personal Author:
    Kreiss, Kathleen
    Published Date:
    Jun 17 2016
    Source:
    Toxicology. 388:48-54.
    Description:
    For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the a...
    File Type:
    Filetype[PDF - 328.71 KB]