Emergency Department Visits by Adults for Psychiatric Medication Adverse Events
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

For very narrow results

When looking for a specific result

Best used for discovery & interchangable words

Recommended to be used in conjunction with other fields

Dates

to

Document Data
Library
People
Clear All
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Emergency Department Visits by Adults for Psychiatric Medication Adverse Events

Filetype[PDF-266.84 KB]


English

Details:

  • Alternative Title:
    JAMA Psychiatry
  • Personal Author:
  • Description:
    IMPORTANCE

    In 2011, an estimated 26.8 million US adults used prescription medications for mental illness.

    OBJECTIVE

    To estimate the numbers and rates of adverse drug event (ADE) emergency department (ED) visits involving psychiatric medications among US adults between January 1, 2009, and December 31, 2011.

    DESIGN AND SETTING

    Descriptive analyses of active, nationally representative surveillance of ADE ED visits using the National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance system and of drug prescribing during outpatient visits using the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey.

    PARTICIPANTS

    Medical records from national probability samples of ED and outpatient visits by adults 19 years or older were reviewed and analyzed.

    EXPOSURES

    Antidepressants, antipsychotics, lithium salts, sedatives and anxiolytics, and stimulants.

    MAIN OUTCOMES AND MEASURES

    National estimates of ADE ED visits resulting from therapeutic psychiatric medication use and of psychiatric medication ADE ED visits per 10 000 outpatient visits at which psychiatric medications were prescribed.

    RESULTS

    From 2009 through 2011, there were an estimated 89 094 (95% CI, 68 641–109 548) psychiatric medication ADE ED visits annually, with 19.3% (95% CI, 16.3%–22.2%) resulting in hospitalization and 49.4% (95% CI, 46.5%–52.4%) involving patients aged 19 to 44 years. Sedatives and anxiolytics, antidepressants, antipsychotics, lithium salts, and stimulants were implicated in an estimated 30 707 (95% CI, 23 406–38 008), 25 377 (95% CI, 19 051–31 704), 21 578 (95% CI, 16 599–26 557), 3620 (95% CI, 2311–4928), and 2779 (95% CI, 1764–3794) respective ADE ED visits annually. Antipsychotics and lithium salts were implicated in 11.7 (95% CI, 10.1–13.2) and 16.4 (95% CI, 13.0–19.9) ADE ED visits per 10 000 outpatient prescription visits, respectively, compared with 3.6 (95% CI, 3.2–4.1) for sedatives and anxiolytics, 2.9 (95% CI, 2.3–3.5) for stimulants, and 2.4 (95% CI, 2.1–2.7) for antidepressants. The commonly used sedative zolpidem tartrate was implicated in 11.5% (95% CI, 9.5%–13.4%) of all adult psychiatric medication ADE ED visits and in 21.0% (95% CI, 16.3%–25.7%) of visits involving adults 65 years or older, in both cases significantly more than any other psychiatric medication.

    CONCLUSIONS AND RELEVANCE

    Psychiatric medications are implicated in many ADEs treated in US EDs. Efforts to reduce ADEs should include adults of all ages but might prioritize medications causing high numbers and rates of ED visits.

  • Keywords:
  • Source:
  • Pubmed ID:
    25006837
  • Pubmed Central ID:
    PMC4703317
  • Document Type:
  • Funding:
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:

You May Also Like

Checkout today's featured content at stacks.cdc.gov