Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

Matsumoto, Rae R.; Seminerio, Michael J.; Turner, Ryan C.; Robson, Matthew J.; Nguyen, Linda; Miller, Diane B.; O’Callaghan, James P.

doi:10.1016/j.pharmthera.2014.05.001

i

Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

Supporting Files

May 14 2014
By Matsumoto, Rae R. ; Seminerio, Michael J. ; Turner, Ryan C. ; ...

Details

Alternative Title:

Pharmacol Ther
Personal Author:

Matsumoto, Rae R. ; Seminerio, Michael J. ; Turner, Ryan C. ; Robson, Matthew J. ; Nguyen, Linda ; Miller, Diane B. ; O’Callaghan, James P.
Description:

Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.
Subjects:

Animals Article Autonomic Nervous System Body Temperature Body Temperature Regulation Central Nervous System Stimulants Dopamine Drug Overdose Fever Heat Production Humans Hypertension Hyperthermia Immune Metabolism Methamphetamine Neurotransmitter Reactive Oxygen Species Stress Tachycardia Thermoregulation Toxicity Vasoconstriction
Source:

Pharmacol Ther. 144(1):28-40.
Pubmed ID:

24836729
Pubmed Central ID:

PMC4700537
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States ; DA013978/DA/NIDA NIH HHS/United States ; GM081741/GM/NIGMS NIH HHS/United States ; NS007491/NS/NINDS NIH HHS/United States ; R01 DA013978/DA/NIDA NIH HHS/United States ; T32 GM081741/GM/NIGMS NIH HHS/United States ; T32 NS007491/NS/NINDS NIH HHS/United States
Volume:

144
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:e77c9dd86a3c5bceb6ca04ea2d363f046296d1cb036955734b1c16f16d1814c4
Download URL:

https://stacks.cdc.gov/view/cdc/37250/cdc_37250_DS1.pdf
File Type:

[PDF - 721.52 KB ]

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