Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia

Details

• Personal Author:
  Matsumoto RR ; Miller DB ; Nguyen L ; O'Callaghan JP ; Robson MJ ; Seminerio MJ ; Turner RC
• Description:
  Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. [Description provided by NIOSH]
• Subjects:
  Body Temperature Hazardous Substances Morbidity Mortality Nervous System Occupational Health Safety Substance-Related Disorders
• Keywords:
  Author Keywords: Autonomic Nervous System Body-temperature Central-nervous-system Drug-abuse Drugs Hyperthermia Methamphetamine Morbidity-rates Mortality-surveys Proteins Reactive Oxygen Species Thermoregulation Toxic-dose Toxic-effects Toxicity

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• ISSN:
  0163-7258
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28-40
• Volume:
  144
• Issue:
  1
• NIOSHTIC Number:
  nn:20044420
• Citation:
  Pharmacol Ther 2014 Oct; 144(1):28-40
• Contact Point Address:
  Rae R. Matsumoto, West Virginia University, School of Pharmacy, One Medical Center Drive, Morgantown, WV 26506
• Email:
  rmatsumoto@hsc.wvu.edu
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  True
• Source Full Name:
  Pharmacology & Therapeutics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed9e10f3c41722be670cdc425a8f64d2e160ff0eeebe22941b8318563757f3ed51551abc598b8d7e0bcfddb56a6d062ab570218d313715993f7af733f86ce3b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/200126/cdc_200126_DS1.pdf
• File Type:
  [PDF - 1.85 MB ]