Details:

Alternative Title:
J Toxicol Environ Health A
Personal Author:
Shvedova, Anna A. ; Yanamala, Naveena ; Murray, Ashley R. ; Kisin, Elena R. ; Khaliullin, Timur ; ... More +
Shvedova, Anna A. ; Yanamala, Naveena ; Murray, Ashley R. ; Kisin, Elena R. ; Khaliullin, Timur ; Hatfield, Meghan K. ; Tkach, Alexey V. ; Krantz, Q. T. ; Nash, David ; King, Charly ; Gilmour, M. Ian ; Gavett, Stephen H. Less -
Description:
Over the past decade, soy biodiesel (BD) has become a first alternative energy source that is economically viable and meets requirements of the Clean Air Act. Due to lower mass emissions and reduced hazardous compounds compared to diesel combustion emissions (CE), BD exposure is proposed to produce fewer adverse health effects. However, considering the broad use of BD and its blends in different industries, this assertion needs to be supported and validated by mechanistic and toxicological data. Here, adverse effects were compared in lungs and liver of BALB/cJ mice after inhalation exposure (0, 50, 150, or 500 μg/m3; 4 h/d, 5 d/wk, for 4 wk) to CE from 100% biodiesel (B100) and diesel (D100). Compared to D100, B100 CE produced a significant accumulation of oxidatively modified proteins (carbonyls), an increase in 4-hydroxynonenal (4-HNE), a reduction of protein thiols, a depletion of antioxidant gluthatione (GSH), a dose-related rise in the levels of biomarkers of tissue damage (lactate dehydrogenase, LDH) in lungs, and inflammation (myeloperoxidase, MPO) in both lungs and liver. Significant differences in the levels of inflammatory cytokines interleukin (IL)-6, IL-10, IL-12p70, monocyte chemoattractant protein (MCP)-1, interferon (IFN) γ, and tumor necrosis factor (TNF)-α were detected in lungs and liver upon B100 and D100 CE exposures. Overall, the tissue damage, oxidative stress, inflammation, and cytokine response were more pronounced in mice exposed to BD CE. Further studies are required to understand what combustion products in BD CE accelerate oxidative and inflammatory responses.
Subjects:
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Administration, Inhalation Air Pollutants Animals Article Biofuels Biomarkers Cytokines Dose-Response Relationship, Drug Female Inhalation Exposure L-Lactate Dehydrogenase Liver Lung Mice Mice, Inbred BALB C Oxidative Stress Peroxidase Vehicle Emissions
Source:
J Toxicol Environ Health A. 76(15):907-921.
Pubmed ID:
24156694
Pubmed Central ID:
PMC4671493
Document Type:
Journal Article
Funding:
2927ZKCY/PHS HHS/United States ; CC999999/Intramural CDC HHS/United States
2927ZKCY/PHS HHS/United States ; CC999999/Intramural CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:02930fb5152c9f85c12620f13c7e5c9924767e7bbc458bb2ed2ad7946a47710e
Download URL:
https://stacks.cdc.gov/view/cdc/36769/cdc_36769_DS1.pdf
File Type:

Supporting Files

• 	NIHMS732119-supplement-Supplement.pdf	pdf
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