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Comparison of Acute Health Effects from Exposures to Diesel and Biodiesel Fuel Emissions
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Details:
  • Pubmed ID:
    26147538
  • Pubmed Central ID:
    PMC4479787
  • Funding:
    1S10 RR028868-01/RR/NCRR NIH HHS/United States
    CA023074/CA/NCI NIH HHS/United States
    ES06694/ES/NIEHS NIH HHS/United States
    P30 CA023074/CA/NCI NIH HHS/United States
    P30 ES006694/ES/NIEHS NIH HHS/United States
    R01 OH009878/OH/NIOSH CDC HHS/United States
    R01 OH009878/OH/NIOSH CDC HHS/United States
    S10 RR028868/RR/NCRR NIH HHS/United States
    T32 ES007091/ES/NIEHS NIH HHS/United States
    T32 ES007091/ES/NIEHS NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    OBJECTIVES

    To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions.

    METHODS

    We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting: lung function; lung and systemic inflammation; novel biomarkers of exposure; and oxidative stress were assessed.

    RESULTS

    B75 reduced respirable diesel particulate matter (rDPM) by 20%. Lung function declined significantly more following exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative stress, was not significantly changed following either exposure.

    CONCLUSIONS

    Use of B75 lowered rDPM exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use.