Comparison of Acute Health Effects from Exposures to Diesel and Biodiesel Fuel Emissions

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Mehus, Aaron A. ; Reed, Rustin J. ; Lee, Vivien S.T. ; Littau, Sally R. ; Hu, Chengcheng ; Lutz, Eric A. ; Burgess, Jefferey L.
• Description:
  OBJECTIVES
  
  To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions.
  
  METHODS
  
  We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting: lung function; lung and systemic inflammation; novel biomarkers of exposure; and oxidative stress were assessed.
  
  RESULTS
  
  B75 reduced respirable diesel particulate matter (rDPM) by 20%. Lung function declined significantly more following exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative stress, was not significantly changed following either exposure.
  
  CONCLUSIONS
  
  Use of B75 lowered rDPM exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use.
  
  
• Keywords:
  Adult Air Pollutants, Occupational Air Pollution, Indoor Biofuels Biomarkers Endpoint Determination Environmental Monitoring Female Gasoline Healthy Volunteers Humans Inhalation Exposure Male Mining Occupational Exposure Oxidative Stress Particulate Matter Respiratory Function Tests Vehicle Emissions

  More +
• Source:
  J Occup Environ Med. 57(7):705-712
• Pubmed ID:
  26147538
• Pubmed Central ID:
  PMC4479787
• Document Type:
  Journal Article
• Funding:
  R01 OH009878/OH/NIOSH CDC HHSUnited States/ ; P30 CA023074/CA/NCI NIH HHSUnited States/ ; T32 ES007091/ES/NIEHS NIH HHSUnited States/ ; ES06694/ES/NIEHS NIH HHSUnited States/ ; P30 ES006694/ES/NIEHS NIH HHSUnited States/ ; 1S10 RR028868-01/RR/NCRR NIH HHSUnited States/ ; CA023074/CA/NCI NIH HHSUnited States/ ; S10 RR028868/RR/NCRR NIH HHSUnited States/
• Volume:
  57
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:54bcd37c6d10abfc30bf47c3796c96d4ef90a305b814b09901e16f9b2405973d
• Download URL:
  https://stacks.cdc.gov/view/cdc/32014/cdc_32014_DS1.pdf
• File Type:
  [PDF - 232.12 KB ]