Comparison of Acute Health Effects from Exposures to Diesel and Biodiesel Fuel Emissions

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Mehus, Aaron A. ; Reed, Rustin J. ; Lee, Vivien S.T. ; Littau, Sally R. ; Hu, Chengcheng ; Lutz, Eric A. ; Burgess, Jefferey L.
• Description:
  OBJECTIVES ; To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions. ; METHODS ; We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting: lung function; lung and systemic inflammation; novel biomarkers of exposure; and oxidative stress were assessed. ; RESULTS ; B75 reduced respirable diesel particulate matter (rDPM) by 20%. Lung function declined significantly more following exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative stress, was not significantly changed following either exposure. ; CONCLUSIONS ; Use of B75 lowered rDPM exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use.
• Keywords:
  • Adult
  • Air Pollutants, Occupational
  • Air Pollution, Indoor
  • Biofuels
  • Biomarkers
  • Endpoint Determination
  • Environmental Monitoring
  • Female
  • Gasoline
  • Healthy Volunteers
  More +
• Source:
  J Occup Environ Med. 57(7):705-712
• Pubmed ID:
  26147538
• Pubmed Central ID:
  PMC4479787
• Document Type:
  Journal Article
• Funding:
  R01 OH009878/OH/NIOSH CDC HHSUnited States/ ; P30 CA023074/CA/NCI NIH HHSUnited States/ ; T32 ES007091/ES/NIEHS NIH HHSUnited States/ ; ES06694/ES/NIEHS NIH HHSUnited States/ ; P30 ES006694/ES/NIEHS NIH HHSUnited States/ ; 1S10 RR028868-01/RR/NCRR NIH HHSUnited States/ ; CA023074/CA/NCI NIH HHSUnited States/ ; S10 RR028868/RR/NCRR NIH HHSUnited States/
• Volume:
  57
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/32014/cdc_32014_DS1.pdf
• File Type:
  [PDF - 232.12 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:54bcd37c6d10abfc30bf47c3796c96d4ef90a305b814b09901e16f9b2405973d