Comparison of Acute Health Effects from Exposures to Diesel and Biodiesel Fuel Emissions

Mehus, Aaron A.; Reed, Rustin J.; Lee, Vivien S.T.; Littau, Sally R.; Hu, Chengcheng; Lutz, Eric A.; Burgess, Jefferey L.

doi:10.1097/JOM.0000000000000473

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Comparison of Acute Health Effects from Exposures to Diesel and Biodiesel Fuel Emissions

Published Date:

Jul 2015

Publisher's site:

http://dx.doi.org/10.1097/JOM.0000000000000473 New Site Icon

Source:

J Occup Environ Med. 57(7):705-712.

[PDF-232.12 KB]

Details:

Alternative Title:

J Occup Environ Med

Personal Author:

Mehus, Aaron A. ; Reed, Rustin J. ; Lee, Vivien S.T. ; Littau, Sally R. ; Hu, Chengcheng ; ... More ▼

Description:

OBJECTIVES

To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions.

METHODS

We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting: lung function; lung and systemic inflammation; novel biomarkers of exposure; and oxidative stress were assessed.

RESULTS

B75 reduced respirable diesel particulate matter (rDPM) by 20%. Lung function declined significantly more following exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative stress, was not significantly changed following either exposure.

CONCLUSIONS

Use of B75 lowered rDPM exposure and some associated acute health effects, although lung and systemic inflammation were not reduced compared with diesel use.

Subject:

[+]

Pubmed ID:

26147538

Pubmed Central ID:

PMC4479787

Document Type:

Journal Article

Funding:

1S10 RR028868-01/RR/NCRR NIH HHS/United States ; CA023074/CA/NCI NIH HHS/United States ; ES06694/ES/NIEHS NIH HHS/United States ; P30 CA023074/CA/NCI NIH HHS/United States ; P30 ES006694/ES/NIEHS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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	NIHMS678274-supplement-Supplemental_Digital_Content_2.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
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	NIHMS678274-supplement-Supplemental_Digital_Content_4.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms678274.nxml	application/octet-stream

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