Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive Acoustic Biosensing

Details

• Alternative Title:
  Adv Healthc Mater
• Personal Author:
  Chattaraj, Rajarshi ; Mohan, Praveena ; Besmer, Jeremy D. ; Goodwin, Andrew P.
• Description:
  Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin is sensed down to 1 × 10(-13) m, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.
• Keywords:
  Biomarkers Biomedical Applications Biosensing Techniques Biotin Colloids Fluorocarbons Humans Nanostructures Self-Assembly Sensors/Biosensors Stimuli-Responsive Materials Streptavidin Ultrasonics Volatilization

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• Source:
  Adv Healthc Mater. 4(12):1790-1795
• Pubmed ID:
  26084414
• Pubmed Central ID:
  PMC4556242
• Document Type:
  Journal Article
• Funding:
  R00 CA153935/CA/NCI NIH HHSUnited States/ ; R21 EB018034/EB/NIBIB NIH HHSUnited States/ ; DP2EB020401/DP/NCCDPHP CDC HHSUnited States/ ; DP2 EB020401/EB/NIBIB NIH HHSUnited States/ ; R00CA153935/CA/NCI NIH HHSUnited States/ ; R21EB018034/EB/NIBIB NIH HHSUnited States/
• Volume:
  4
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8f629ca696899f349e1889426fe8f865a83974f8d6f13b909e599318ef24d6f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/35673/cdc_35673_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]