Molecular Epidemiology of Hospital Outbreak of Middle East
Respiratory Syndrome, Riyadh, Saudi Arabia, 2014

Fagbo, Shamsudeen F.; Skakni, Leila; Chu, Daniel K.W.; Garbati, Musa A.; Joseph, Mercy; Peiris, Malik; Hakawi, Ahmed M.

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Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014

Published Date:

Nov 2015

Source:

Emerg Infect Dis. 21(11):1981-1988

Language:

English

[PDF-1.55 MB]

Details:

Personal Authors:

Fagbo, Shamsudeen F. ; Skakni, Leila ; Chu, Daniel K.W. ; Garbati, Musa A. ; Joseph, Mercy ; ... More ▼

Keywords:

[+]

Pubmed ID:

26484549

Pubmed Central ID:

PMC4622263

Description:

We investigated an outbreak of Middle East respiratory syndrome (MERS) at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, during March 29-May 21, 2014. This outbreak involved 45 patients: 8 infected outside KFMC, 13 long-term patients at KFMC, 23 health care workers, and 1 who had an indeterminate source of infection. Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013-February 10, 2014). This finding suggested continued health care-associated transmission for 5 months. Molecular epidemiology documented multiple external introductions in a seemingly contiguous outbreak and helped support or refute transmission pathways suspected through epidemiologic investigation.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Funding:

HHSN272201400006C/AI/NIAID NIH HHS/United States
HHSN272201500006C/PHS HHS/United States

Supporting Files:

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