Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Fagbo, Shamsudeen F. ; Skakni, Leila ; Chu, Daniel K.W. ; Garbati, Musa A. ; Joseph, Mercy ; ... More +
Fagbo, Shamsudeen F. ; Skakni, Leila ; Chu, Daniel K.W. ; Garbati, Musa A. ; Joseph, Mercy ; Peiris, Malik ; Hakawi, Ahmed M. Less -
Description:
We investigated an outbreak of Middle East respiratory syndrome (MERS) at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, during March 29-May 21, 2014. This outbreak involved 45 patients: 8 infected outside KFMC, 13 long-term patients at KFMC, 23 health care workers, and 1 who had an indeterminate source of infection. Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013-February 10, 2014). This finding suggested continued health care-associated transmission for 5 months. Molecular epidemiology documented multiple external introductions in a seemingly contiguous outbreak and helped support or refute transmission pathways suspected through epidemiologic investigation.
Subjects:
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Coronavirus Coronavirus Infections Disease Outbreaks Expedited Health Care Workers Humans Iatrogenic Disease MERS MERS-CoV Middle East Respiratory Syndrome Middle East Respiratory Syndrome Coronavirus Molecular Epidemiology Molecular Epidemiology Of Hospital Outbreak Of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014 Mutation Nosocomial Infection Phylogeny Research Respiratory Infections Respiratory Tract Infections Saudi Arabia Transmission Viruses Zoonoses
Source:
Emerg Infect Dis. 21(11):1981-1988
Pubmed ID:
26484549
Pubmed Central ID:
PMC4622263
Document Type:
Journal Article
Funding:
HHSN272201400006C/AI/NIAID NIH HHS/United States ; HHSN272201500006C/PHS HHS/United States
HHSN272201400006C/AI/NIAID NIH HHS/United States ; HHSN272201500006C/PHS HHS/United States Less -
Place as Subject:
Saudi Arabia
Location:
Middle East
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:80692f2c5ab9caaf46dc96b4097d443c2d8a0ec401c20c6a57fe483868c532b1
Download URL:
https://stacks.cdc.gov/view/cdc/35556/cdc_35556_DS1.pdf
File Type:

Supporting Files

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  	15-0944-Techapp-s1.pdf	pdf
  	15-0944-Techapp-s2.xlsx	xlsx

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