CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014
-
Nov 2015
-
-
Source: Emerg Infect Dis. 21(11):2029-2035
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (Ct) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median Ct of 31.0 for the upstream of the E gene target for 41 (40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p=0.0087). In multivariable regression analyses, risk factors for death were age>60 years), underlying illness, and decreasing Ct for each 1-point decrease in Ct). Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.
-
Subjects:
-
Source:
-
Pubmed ID:26488195
-
Pubmed Central ID:PMC4622256
-
Document Type:
-
Place as Subject:
-
Location:
-
Volume:21
-
Issue:11
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: