Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina

Details

• Alternative Title:
  BMC Infect Dis
• Personal Author:
  Marcone, Débora Natalia ; Durand, Lizette O. ; Azziz-Baumgartner, Eduardo ; Vidaurreta, Santiago ; Ekstrom, Jorge ; Carballal, Guadalupe ; Echavarria, Marcela
• Description:
  Background
  
  Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries.
  
  Methods
  
  During 2008–2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5 years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction.
  
  Results
  
  The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6 months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6–23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362–789).
  
  Conclusions
  
  Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.
  
  
• Subjects:
  Child, Hospitalized Child, Preschool Cohort Studies Demography Emergency Service, Hospital Female Humans Incidence Infant Male Metapneumovirus Microscopy, Fluorescence Orthomyxoviridae Outpatients Paramyxoviridae Infections Prospective Studies Real-Time Polymerase Chain Reaction Respiratory Syncytial Viruses Respiratory Tract Infections Rhinovirus Virus Diseases

  More +
• Source:
  BMC Infect Dis. 15.
• Pubmed ID:
  26497393
• Pubmed Central ID:
  PMC4619328
• Document Type:
  Journal Article
• Place as Subject:
  Argentina
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2daf99c4b6b111b73798e0835c92f3175d40a421be77319d305f01b79dffa3ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/35500/cdc_35500_DS1.pdf
• File Type:
  [PDF - 542.51 KB ]